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2,4-Dichloro-5,8-dimethoxyquinoline is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

63070-62-2

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63070-62-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 63070-62-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,0,7 and 0 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 63070-62:
(7*6)+(6*3)+(5*0)+(4*7)+(3*0)+(2*6)+(1*2)=102
102 % 10 = 2
So 63070-62-2 is a valid CAS Registry Number.

63070-62-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4-dichloro-5,8-dimethoxyquinoline

1.2 Other means of identification

Product number -
Other names 5,8-dimethoxy-2,4-dichloroquinoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:63070-62-2 SDS

63070-62-2Relevant academic research and scientific papers

5-Methoxyquinoline derivatives as a new class of EZH2 inhibitors

Xiang, Pu,Jie, Hui,Zhou, Yang,Yang, Bo,Wang, Hui-Juan,Hu, Jing,Hu, Jian,Yang, Sheng-Yong,Zhao, Ying-Lan

, p. 7620 - 7636 (2015/05/20)

A series of quinoline derivatives was synthesized and biologically evaluated as Enhancer of Zeste Homologue 2 (EZH2) inhibitors. Structure-activity relationship (SAR) studies led to the discovery of 5-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinolin-4-amine (5k), which displayed an IC50 value of 1.2 μM against EZH2, decreased global H3K27me3 level in cells and also showed good anti-viability activities against two tumor cell lines. Due to the low molecular weight and the fact that no quinoline derivative has been reported as an EZH2 inhibitor, this compound could serve as a lead compound for further optimization.

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