79784-26-2Relevant academic research and scientific papers
Design, synthesis and molecular docking of substituted 3-hydrazinyl-3-oxo-propanamides as anti-tubercular agents
Naqvi, Arshi,Malasoni, Richa,Srivastava, Akansha,Pandey, Rishi Ranjan,Dwivedi, Anil Kumar
supporting information, p. 5181 - 5184 (2014/12/11)
Based on the anti-mycobacterial activity of various acid hydrazides, a series of substituted 3-hydrazinyl-3-oxo-propanamides has been designed. The target compounds have been synthesized from diethylmalonate using substituted amines and hydrazine hydrate
SYNTHESIS OF 2,5,8(1H)-QUINOLINETRIONE DERIVATIVES THROUGH VILSMEIER-HAACK FORMYLATION OF 2,5-DIMETHOXYANILIDES
Alonso, Miguel Angel,Blanco, M del Mar,Avendano, Carmen,Menendez, J. Carlos
, p. 2315 - 2326 (2007/10/02)
The preparation of 2,5,8(1H)-quinolinetrione derivatives bearing both electron-withdrawing and electron-releasing groups at C3 is described.The reaction sequence employed involves Vilsmeier-Haack cyclization of 2,5-dimethoxyanilides into 3-substituted 5,8-dimethoxy-2-chloroquinolinolines, followed by hydrolysis to the corresponding 2(1H)-quinolinones and oxidative demethylation with cerium ammonium nitrate.
