446-29-7

Basic information

• Product Name: 4'-Fluoro-2'-methyacetophenone
• Synonyms: 4'-Fluoro-2'-methyacetophenone;1-(4-Fluoro-2-methylphenyl)ethanone;4-fluoro-2-methylphenacyl bromide;1-(4-Fluoro-2-methylphenyl)
• CAS NO: 446-29-7
• Molecular Formula: C₉H₉FO
• Molecular Weight: 152.17
• Mol File: 446-29-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 219℃
• Flash Point: 84℃
• Appearance: /
• Density: 1.075
• Refractive Index: 1.5120
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4'-Fluoro-2'-methyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Fluoro-2'-methyacetophenone(446-29-7)
• EPA Substance Registry System: 4'-Fluoro-2'-methyacetophenone(446-29-7)

Safety Data

• Hazardous Substances Data: 446-29-7(Hazardous Substances Data)

Usage

General Description

4'-Fluoro-2'-methyacetophenone is a chemical compound that belongs to the class of organic compounds known as acetophenones. It is a pale yellow liquid with a molecular formula C9H9FO and a molecular weight of 154.17 g/mol. 4'-Fluoro-2'-methyacetophenone is primarily used as an intermediate in the production of various pharmaceuticals and agrochemicals. It is also used in the synthesis of other organic compounds and can be employed as a flavoring agent in the food industry. 4'-Fluoro-2'-methyacetophenone is known to have a fruity odor and is considered to be a potential irritant to the skin, eyes, and respiratory system.

Upstream product

• 352-70-5 m-Fluorotoluene 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 700-34-5 (RS)-1-(4-fluoro-2-methylphenyl)ethanol 
• 63082-45-1 4-fluoro-2-methylbenzaldehyde 
• 111-34-2 -butyl vinyl ether 
• 452-63-1 2-Bromo-5-fluorotoluene 

Downstream Products

• 443-19-6 4-dimethylamino-4'-fluoro-2'-methyl-trans-chalcone 
• 87054-24-8 2,3-Bis-(4-fluoro-2-methyl-phenyl)-butane-2,3-diol 
• 79784-33-1 4-fluoro-2-methylphenylglyoxal 
• 76475-81-5 3-Dimethylamino-1-(4-fluoro-2-methyl-phenyl)-propan-1-one; compound with oxalic acid 
• 79784-47-7 5-(4-fluoro-2-methylphenyl)-3-mercapto-1,2,4-triazine 
• 3825-64-7 4-fluoro-2-methyl-1-vinylbenzene 
• 1415838-54-8 8-(butylamino)-7-(2-(butylimino)-2-(4-fluoro-2-methylphenyl)ethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione 
• 1415838-63-9 C₁₉H₂₀FN₅O₂ 
• 113334-01-3 C₂₄H₂₄F₂N₂O₂ 
• 113333-97-4 C₁₈H₁₃F₂NO₂ 
• 120624-71-7 5-Fluoro-3-[2-(4-fluoro-2-methyl-phenyl)-2-oxo-eth-(Z)-ylidene]-1,3-dihydro-indol-2-one 
• 154374-25-1 (E)-1-(4-Fluoro-2-methyl-phenyl)-3-(2-phenyl-1H-indol-3-yl)-propenone 
• 76475-85-9 1-(4-Fluoro-2-methyl-phenyl)-3-{4-[3-(4-fluoro-2-methyl-phenyl)-3-oxo-propyl]-piperazin-1-yl}-propan-1-one; hydrochloride 
• 76475-84-8 1-(4-Fluoro-2-methyl-phenyl)-3-piperidin-1-yl-propan-1-one; hydrochloride 

Relevant articles and documents

Simple and environment-friendly chemical synthesis method of 4-fluoro-2-methyl benzoic acid

The invention relates to a simple and environment-friendly chemical synthesis method of 4-fluoro-2-methyl benzoic acid. According to the synthesis method, m-fluorotoluene and acetyl chloride are takenas starting raw materials, and are subjected to a Friedel-Crafts acylation reaction under the catalytic action of anhydrous aluminum trichloride, a haloform reaction is carried out with sodium hypochlorite, two isomers of 4-fluoro-2-methyl benzoic acid and 2-fluoro-4-methyl benzoic acid are simultaneously obtained after hydrolysis, and the isomers are separated through re-crystallizing so as to obtain the target product 4-fluoro-2-methylbenzoic acid. The route is mild in reaction condition, low in cost, environment-friendly and suitable for industrial production.

Novel 5-HT2A receptor ligands

Compounds of formula I: are antagonists of the human 5-HT2A receptor, and hence useful in treatment or prevention of a variety of neurological conditions.