63096-06-0

Upstream product

• 63096-04-8 α-Boc-Amino-α-methoxy-β-phenylpropionsaeure-methylester 
• 94413-73-7 α-Azidozimtsaeuremethylester 
• 108-24-7 acetic anhydride 
• 100-52-7 benzaldehyde 
• 51987-73-6 methyl 2-tert-butoxycarbonylamino-3-phenylpropanoate 
• 67-56-1 methanol 
• 84759-65-9 N-benzyloxycarbonyldehydrophenylalanine 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 128070-30-4 (E)-3-Phenyl-2-(3-phenyl-ureido)-acrylic acid methyl ester 
• 112792-67-3 pentacarbonyl(α,β-didehydrophenylalanin-methylester)rhenium(I) tetrafluoroborate 
• 112792-62-8 trans-dichlorobis(dehydrophenylalanin-methylester)palladium(II) 

Relevant academic research and scientific papers

CuII/TEMPO-promoted one-pot synthesis of highly substituted pyrimidines from amino acid esters

A novel, Cu(OAc)2/TEMPO promoted one-step approach for the preparation of fully substituted pyrimi-dines from readily available amino acid esters has been described. In this reaction, the amino acid esters act as the only N-C sources for the construction of corresponding pyrimidines. The mechanism of this process includes oxidative dehydrogenation, the generation of an imine radical, and a formal [3+3] cycloaddition. This methodology proves to be a high atom-economic and straightforward strategy for the synthesis of pyrimidines and diverse substrates which are substituted by various functional groups have been afforded in moderate to good yield.

Dorsamin-A's, glycerolipids carrying a dehydrophenylalanine ester moiety from the seed-eating larvae of the bruchid beetle Bruchidius dorsalis

Using a TLC autographic assay for radical-scavenging activity with the ABTS radical, the presence of lipophilic antioxidants in the larvae of the wild bruchid seed beetle Bruchidius dorsalis was detected. Assay-guided fractionation of the CHCl3-soluble fraction of the larvae resulted in the isolation of new glycerolipids, designated dorsamin-A763, -A737, -A765, -A739, and -A767, comprising 1,2-diacyl-sn-glycero-3-dehydrophenylalanine ester structural units. The ABTS radical scavenging activity of the dorsamin-A's was comparable with or stronger than that of Trolox.

AMINO ACIDS AS SYNTHONS FOR HETEROCYCLES. FORMATION OF 1,2,4-TRIAZINE DERIVATIVES

Transformation of the amino group of amino acids into an amidine and subsequent treatment with hydrazine leads to 1,2,4-triazine-6(1H)-ones.The method described is a new synthetic approach.Unsaturated amino acids gave imidazol-5-one derivatives after the

Synthesis of Unsaturated and Saturated Aminoacid Derivatives by Cathodic Reduction of Azidocinnamic Esters

Cathodic reduction of α-azidocinnamic ester under aprotic conditions on Hg, Pt, or graphite electrodes can be directed to high yields of N,N-diacylated dehydroaminoacid derivates (f.i. addition of acetic anhydride) or to almost quantitative yields of α-am