631-66-3

Basic information

• Product Name: pyruvamide
• Synonyms: pyruvamide;1-Amino-1,2-propanedione;2-Oxopropanamide;Pyruvic acid amide
• CAS NO: 631-66-3
• Molecular Formula: C₃H₅NO₂
• Molecular Weight: 87.08
• Mol File: 631-66-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 123-124 °C
• Boiling Point: 175.8°C at 760 mmHg
• Flash Point: 60.1°C
• Appearance: /
• Density: 1.146g/cm³
• Vapor Pressure: 1.13mmHg at 25°C
• Refractive Index: 1.427
• PKA: 13.37±0.50(Predicted)
• CAS DataBase Reference: pyruvamide(CAS DataBase Reference)
• NIST Chemistry Reference: pyruvamide(631-66-3)
• EPA Substance Registry System: pyruvamide(631-66-3)

Safety Data

• Hazardous Substances Data: 631-66-3(Hazardous Substances Data)

Usage

General Description

Pyruvamide, also known as 2-oxo-N-phenylacetamide, is a synthetic compound with the molecular formula C8H9NO2. It is commonly used as an intermediate in the production of various pharmaceuticals and agrochemicals. Pyruvamide is known for its anticonvulsant and anti-cancer properties and has been studied for its potential application in the treatment of epilepsy and various types of tumors. Its chemical structure consists of a pyruvic acid moiety linked to an amide functional group, making it a versatile building block for the synthesis of complex organic molecules. Pyruvamide is also used as a reagent in organic synthesis to introduce the pyruvamide motif into different molecular frameworks.

InChI:InChI=1/C3H5NO2/c1-2(5)3(4)6/h1H3,(H2,4,6)

Upstream product

• 57383-88-7 C₄H₁₀N₄O₃ 
• 588-72-7 [(E)-2-bromoethenyl]benzene 
• 138228-58-7 N-benzylidene-D,L-alanineamide 
• 35572-78-2 2-amino-4,6-dinitrotoluene 
• 3998-25-2 acetyl isocyanate 
• 95-53-4 o-toluidine 
• 5408-04-8 ethyl 2-hydroxyimino-3-oxobutanoate 
• 104-94-9 4-methoxy-aniline 
• 106-49-0 p-toluidine 
• 90-04-0 2-methoxy-phenylamine 
• 73708-95-9 methyl 3-oxo-2-oximinobutanoate 
• 504-29-0 2-aminopyridine 
• 106-95-6 allyl bromide 
• 100-39-0 benzyl bromide 

Downstream Products

• 127-17-3 2-oxo-propionic acid 
• 69849-55-4 Pyruvamidbenzylimin 
• 69849-56-5 Pyruvamidmethylbenzylimin 
• 57383-88-7 C₄H₁₀N₄O₃ 

Relevant articles and documents

Unexpected Reaction of Oximinoacetoacetate with Amines: A Novel Synthesis of Carbamates

The synthesis of alkyl carbamates by a solvent-free reaction of oximinoacetoacetate and amine at 130C is reported. A preliminary mechanism to this unexpected reaction is also given.

Pyridoxal-catalyzed release of nucleotides

The synthesis of phosphoric esters linking the 5' alcohol of thymidine to the alcohol moiety of L-serine derivatives is reported, together with the pyridoxal-catalyzed β-elimination reaction releasing thymidylate from such compounds. The process was extended to the release of thymidine di- and tri- phosphate.

5-Cyano-prostacyclin derivatives

Stabilized prostacyclins having a wide range of pharmacological activity and long duration of such activity, have the formula STR1 wherein R1 is (a) OR3, wherein R3 is hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic residue; or (b) NHR4 wherein R4 is an acid residue; B is straight-chain or branched alkylene of 2-10 carbon atoms; A is --CH2 --CH2 --, cis--CH=CH--, trans--CH=CH-- or --C C--, W is free or functionally modified hydroxymethylene or free or functionally modified STR2 wherein the OH-group can be in the α- or β-position; D and E together are a direct bond; or D is straight-chain or branched alkylene of 1-5 carbon atoms; and E is oxygen or sulfur or a direct bond, R2 is alkyl, cycloalkyl, optionally substituted aryl or a heterocyclic group; and R5 is free or functionally modified hydroxy; and when R3 is hydrogen, the salts thereof with physiologically compatible bases.