631-66-3

Usage

Uses

Used in Pharmaceutical Industry:
Pyruvamide is used as an intermediate in the production of various pharmaceuticals for its potential application in the treatment of epilepsy and different types of tumors. Its anticonvulsant and anti-cancer properties contribute to the development of new therapeutic agents.
Used in Agrochemical Industry:
Pyruvamide is utilized as an intermediate in the production of agrochemicals, where its unique chemical structure aids in the development of effective compounds for agricultural applications.
Used in Organic Synthesis:
Pyruvamide is used as a reagent in organic synthesis to introduce the pyruvamide motif into different molecular frameworks, enabling the creation of diverse organic molecules for various purposes.

InChI:InChI=1/C3H5NO2/c1-2(5)3(4)6/h1H3,(H2,4,6)

Upstream product

• 57383-88-7 C₄H₁₀N₄O₃ 
• 35572-78-2 2-amino-4,6-dinitrotoluene 
• 3998-25-2 acetyl isocyanate 
• 95-53-4 o-toluidine 
• 5408-04-8 ethyl 2-hydroxyimino-3-oxobutanoate 
• 104-94-9 4-methoxy-aniline 
• 106-49-0 p-toluidine 
• 90-04-0 2-methoxy-phenylamine 
• 73708-95-9 methyl 3-oxo-2-oximinobutanoate 
• 504-29-0 2-aminopyridine 
• 138228-58-7 N-benzylidene-D,L-alanineamide 
• 106-95-6 allyl bromide 
• 100-39-0 benzyl bromide 
• 588-72-7 [(E)-2-bromoethenyl]benzene 

Downstream Products

• 57383-88-7 C₄H₁₀N₄O₃ 
• 69849-56-5 Pyruvamidmethylbenzylimin 
• 69849-55-4 Pyruvamidbenzylimin 
• 127-17-3 2-oxo-propionic acid 

Relevant academic research and scientific papers

Unexpected Reaction of Oximinoacetoacetate with Amines: A Novel Synthesis of Carbamates

The synthesis of alkyl carbamates by a solvent-free reaction of oximinoacetoacetate and amine at 130C is reported. A preliminary mechanism to this unexpected reaction is also given.

Oxidation of aminodinitrotoluenes with ozone: Products and pathways

An investigation of the products from the reaction of ozone with aminodinitrotoluenes (ADNTs) provides information about the oxidation pathway. Studies conducted at low conversions of 2- and 4-ADNT show 2:1 ozone/ADNT stoichiometries, prompt formation of glyoxylic and pyruvic acids, and NO2- and NO3- (NOx) ions. Reaction schemes to account for these results involve a 1,3-dipolar cycloaddition of ozone to selected double bonds of the aromatic ring, leading to ring cleavage. 15N-Labeling experiments indicate that the amino function is not involved in the initial ozone oxidation and eventually is incorporated into pyruvamide (2-ADNT) and oxamic acid (4-ADNT) before being oxidized to nitrate.

Pyridoxal-catalyzed release of nucleotides

The synthesis of phosphoric esters linking the 5' alcohol of thymidine to the alcohol moiety of L-serine derivatives is reported, together with the pyridoxal-catalyzed β-elimination reaction releasing thymidylate from such compounds. The process was extended to the release of thymidine di- and tri- phosphate.

Synthesis of α,α-Disubstituted α-Amino Acid Amides by Phase-Transfer Catalyzed Alkylation

α,α-Disubstituted α-amino acid amides were prepared in 17-88 percent chemical yield by the phase-transfer catalyzed alkylation of N-benzylidene α-H amino acid amides, followed by weak acidic hydrolysis of the Schiff bases.

5-Cyano-prostacyclin derivatives

Stabilized prostacyclins having a wide range of pharmacological activity and long duration of such activity, have the formula STR1 wherein R1 is (a) OR3, wherein R3 is hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic residue; or (b) NHR4 wherein R4 is an acid residue; B is straight-chain or branched alkylene of 2-10 carbon atoms; A is --CH2 --CH2 --, cis--CH=CH--, trans--CH=CH-- or --C C--, W is free or functionally modified hydroxymethylene or free or functionally modified STR2 wherein the OH-group can be in the α- or β-position; D and E together are a direct bond; or D is straight-chain or branched alkylene of 1-5 carbon atoms; and E is oxygen or sulfur or a direct bond, R2 is alkyl, cycloalkyl, optionally substituted aryl or a heterocyclic group; and R5 is free or functionally modified hydroxy; and when R3 is hydrogen, the salts thereof with physiologically compatible bases.