6311-73-5

Basic information

• Product Name: methyl 5-nitro-2,6-dioxo-3H-pyrimidine-4-carboxylate
• Synonyms: methyl 5-nitro-2,6-dioxo-3H-pyrimidine-4-carboxylate;Methyl 5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyriMidine-4-carboxylate;5-NITROOROTIC ACID METHYL ESTER;Methyl 5-Nitrouracil-6-carboxylate;methyl 5-nitro-2,4-dioxo-1H-pyrimidine-6-carboxylate
• CAS NO: 6311-73-5
• Molecular Formula: C6H5N3O6
• Molecular Weight: 215.12
• Mol File: 6311-73-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.68
• Refractive Index: 1.58
• Storage Temp.: 2-8°C
• PKA: 1.66±0.10(Predicted)
• CAS DataBase Reference: methyl 5-nitro-2,6-dioxo-3H-pyrimidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-nitro-2,6-dioxo-3H-pyrimidine-4-carboxylate(6311-73-5)
• EPA Substance Registry System: methyl 5-nitro-2,6-dioxo-3H-pyrimidine-4-carboxylate(6311-73-5)

Safety Data

• Hazardous Substances Data: 6311-73-5(Hazardous Substances Data)

Usage

General Description

Methyl 5-nitro-2,6-dioxo-3H-pyrimidine-4-carboxylate is a synthetic organic compound with the chemical formula C7H5N3O6. It is a nitro-substituted pyrimidine derivative and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. methyl 5-nitro-2,6-dioxo-3H-pyrimidine-4-carboxylate is often utilized in the production of anti-inflammatory, anti-cancer, and anti-viral drugs. It possesses potential biological activities and has drawn interest from researchers for its pharmacological properties. Methyl 5-nitro-2,6-dioxo-3H-pyrimidine-4-carboxylate is a versatile chemical that holds promise in various fields, including medicine and agriculture.

InChI:InChI=1/C6H5N3O6/c1-15-5(11)2-3(9(13)14)4(10)8-6(12)7-2/h1H3,(H2,7,8,10,12)

Upstream product

• 67-56-1 methanol 
• 65717-13-7 5-nitroorotic acid, potassium salt 
• 17687-24-0 2,6-dihydroxy-5-nitropyrimidine-4-carboxylic acid 
• 65-86-1 2,4-dihydroxypyrimidine-6-carboxylic acid 

Downstream Products

• 52047-13-9 methyl 2,6-dichloro-5-nitro-4-pyrimidinecarboxylate 

Relevant articles and documents

Pyrimidine fused ring derivatives and application thereof in medicine

The invention relates to compounds shown in a general formula (I) or stereoisomers, deuterated compounds, solvates, prodrugs, metabolites, pharmaceutically acceptable salts or co-crystal of the compounds, an intermediate and a preparation method of the compounds, and application of the compounds in preparation of drugs for treating diseases related to activity or expression quantity of KRas-G12C.

CARBAZOLE AND CARBOLINE KINASE INHIBITORS

The present invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) compounds inhibit tyrosine kinase activity of Jak2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.

Effect of a-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines

Several A-ring-modified analogues of the DNA-binding antitumor agent DC- 81 (5) have been synthesized in order to study structure- reactivity/cytotoxicity relationships. For two molecules (23 and 30) the modifications required the addition of a fourth rin