63113-00-8

Usage

Uses

Used in Food Industry:
1(3H)-Isobenzofuranone,3-hydroxy-5-methyl-(9CI) is used as a flavoring agent for its sweet, caramel-like aroma, enhancing the taste and aroma of various food products.
Used in Fragrance Industry:
1(3H)-Isobenzofuranone,3-hydroxy-5-methyl-(9CI) is used in fragrance and cosmetic products for its pleasant scent, contributing to the overall sensory experience of these products.
Used in Pharmaceutical Industry:
Due to its unique chemical structure and properties, 1(3H)-Isobenzofuranone,3-hydroxy-5-methyl-(9CI) has potential applications in pharmaceuticals, although further research and development are required to explore its full potential in this field.
Used in Agrochemical Industry:
Similarly, the compound may have potential applications in agrochemicals, but more studies are needed to determine its specific uses and benefits in this industry.
It is important to handle 1(3H)-Isobenzofuranone,3-hydroxy-5-methyl-(9CI) with care, as it may pose health hazards if not used properly. Proper safety measures and guidelines should be followed during its production, use, and disposal to minimize any potential risks.

Upstream product

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• 99-94-5 p-Toluic acid 
• 54120-64-8 5-methylphthalide 
• 1351765-08-6 4-methyl-N,N-diisopropyl-2-formylbenzamide 
• 63112-94-7 2,4-Dibrommethylbenzoesaeuremethylester 
• 23617-71-2 2,4-dimethyl-benzoic acid methyl ester 
• 63113-10-0 5-(bromomethyl)-1,3-dihydroisobenzofuran-1-one 
• 63113-04-2 3-Brom-5-methylphthalid 

Downstream Products

• 63112-98-1 2-Formyl-4-methyl-benzoesaeuremethylester 
• 183545-51-9 2-(2-Carboxy-5-methylbenzyliden)-4-methylindan-1-on 
• 1351765-30-4 (E)-4-methyl-2-(prop-1-enyl)benzoic acid 

Relevant academic research and scientific papers

Chiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters

Utilizing a chiral bicyclic imidazole organocatalyst and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99 % ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure analysis of the key transition states shows that the CH-π interactions and not the previously considered cation/π-π interactions between the catalyst and substrate is the dominant factor giving rise to the observed stereocontrol.

Regioselective Pd-catalyzed aerobic aza-Wacker cyclization for preparation of isoindolinones and isoquinolin-1(2 H)-ones

A switchable regioselective intramolecular aerobic aza-Wacker cyclization catalyzed by palladium is presented. Isoindolinones or isoquinolin-1(2H)-ones could be prepared selectively from the same substrates using different catalysts. The type and steric hindrance of the ligands may be the variables most significant for regiocontrol.

N-heterocyclic inhibitors of TNF-α expression

N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.

N-heterocyclic inhibitors of TNF-alpha expression

N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.

N- heterocyclic inhibitors of TNF-alpha expression

N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.

Aromatic Spiranes XXI [1]: Syntheses of Methyl Substituted Phthalaldehydic Acids and their Ethyl and Methyl Esters as Synthones for Syntheses of Methylated 2,2′-Spirobiindandiones

The isomeric methyl phthalaldehydic acids 11 were obtained from phthalides 4 by bromation (NBS) to the 3-bromo derivatives 7 and subsequent hydrolysis with water. 4 in turn were accessible from dimethyl methyl benzoates 1 by dibromination with NBS and subsequent thermical cyclization to the bromo derivatives 3 which, on catalytic dehalogenation, afforded the phthalides 4. Reaction of 11 with methanol or ethanol gave the pseudo-esters 13 and 14, resp. Short treatment of 11 with diazomethane on the other hand yielded the methyl formyl benzoates 15b to 15e. Prolonged reaction (several hours) gave the oxiranyl compounds 17; in addition, the acetonyl derivatives 18 were also found, obviously formed by a double methylene insertion into 15. All reactions proceeded with good to excellent yields.