54120-64-8

Basic information

• Product Name: 5-Methyl-1,3-dihydroisobenzofuran-1-one
• Synonyms: 5-Methyl-1(3H)-isobenzofuranone;5-Methyl-1,3-dihydroisobenzofuran-1-one;5-Methylphthalide;5-Methylisobenzofuran-1(3H)-one;5-methyl-3H-2-benzofuran-1-one;5-Methyl-3H-isobenzofuran-1-one
• CAS NO: 54120-64-8
• Molecular Formula: C₉H₈O₂
• Molecular Weight: 148.1586
• Mol File: 54120-64-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 104-106 °C
• Boiling Point: 329.2°Cat760mmHg
• Flash Point: 136.1°C
• Appearance: /
• Density: 1.211g/cm³
• Vapor Pressure: 0.000181mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-Methyl-1,3-dihydroisobenzofuran-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methyl-1,3-dihydroisobenzofuran-1-one(54120-64-8)
• EPA Substance Registry System: 5-Methyl-1,3-dihydroisobenzofuran-1-one(54120-64-8)

Safety Data

• Hazardous Substances Data: 54120-64-8(Hazardous Substances Data)

Usage

Uses

5-Methyl-1,3-dihydroisobenzofuran-1-one is a reagent used in the synthesis of γ-lactones.

InChI:InChI=1/C9H8O2/c1-6-2-3-8-7(4-6)5-11-9(8)10/h2-4H,5H2,1H3

Upstream product

• 90534-49-9 1,2-bishydroxymethyl-4-methylbenzene 
• 99-94-5 p-Toluic acid 
• 74-95-3 1,1-dibromomethane 
• 67-56-1 methanol 
• 611-01-8 2,4-dimethyl-benzoic acid 
• 23617-71-2 2,4-dimethyl-benzoic acid methyl ester 
• 4316-23-8 4-methylphthalic acid 
• 19438-61-0 4-methylphthalic anhydride 

Downstream Products

• 63113-00-8 3-hydroxy-5-methylisobenzofuran-1(3H)-one 
• 61099-10-3 4-methyl-2-formylbenzoic acid 

Relevant articles and documents

A g-C3N4-based heterogeneous photocatalyst for visible light mediated aerobic benzylic C-H oxygenations

A metal-free heterogeneous photocatalytic system has been developed for highly efficient benzylic C-H oxygenations using oxygen as an oxidant. This visible light mediated oxidation reaction utilizes graphitic carbon nitride (g-C3N4) as a recyclable, nontoxic and low cost photocatalyst. Mild reaction conditions allow for the generation of synthetically and biologically valued isochromannones, phthalides, isoquinolinones, isoindolinones and xanthones from readily accessible alkyl aromatic precursors in good yields. The heterogeneous nature of the g-C3N4 catalytic system enables easy recovery and recycling as well as the use in multiple runs without loss of activity. The synthetic utility of this "green" methodology was further demonstrated by applying in bioactive and drug valued target syntheses.

Iron(II) pincer-catalyzed synthesis of lactones and lactams through a versatile dehydrogenative domino sequence

The synthesis of lactones and lactams by using iron(II) pincer-catalyzed dehydrogenative methodology was developed. Starting from 1,n-diols or 1,n-amino alcohols, this domino transformation takes place through initial dehydrogenation of the substrates, subsequent intramolecular cyclization, and final oxidation to afford the desired products in good yields. The ability to access heterocycles of different sizes makes this protocol especially versatile, in which two consecutive oxidation reactions are performed without requiring an external oxidant. In this paper, we report the application of the Fe-MACHO-BH complex [carbonylhydrido(tetrahydroborato)[bis(2-diisopropylphosphinoethyl)amino]iron(II)] in this atom-efficient and environmentally benign process, for which molecular hydrogen is formed as the only stoichiometric side product. Just a little pinch: The iron(II) pincer-catalyzed synthesis of lactones and lactams from easily available 1,n-diols and 1,n-amino alcohols is explored. The use of a nontoxic metal as well as the generation of molecular hydrogen as the only stoichiometric byproduct makes this method a highly atom-efficient and environmentally benign process.

Dual fluorescent N-Aryl-2,3-naphthalimides: Applications in ratiometric DNA detection and white organic light-emitting devices

A ten element matrix of 5- and 6-substituted-(2,3)-naphthalimides was prepared for the appropriate placement of substituents necessary to promote dual fluorescence (DF). As prescribed by our balanced seesaw photophysical model this matrix yielded nine new DF dyes out of a possible ten compounds. From this set of nine DF dyes, 4-fluoronaphthalic amide (37) was selected as a probe for ratiometric detection of DNA and demonstration of panchromatic emission.