6312-66-9

Usage

Purine derivative

Contains a double-ring structure of nitrogen and carbon atoms

Diethanolamine

Contains two hydroxyethyl groups

Building block in pharmaceuticals and organic synthesis

Due to the presence of purine and diethanolamine groups

Potential applications in nucleoside analogs and bioactive molecules

Further research and evaluation necessary to understand its potential uses and effects.

Upstream product

• 608-09-3 (7⁽⁹⁾H-purin-6-ylsulfanyl)-acetic acid 
• 111-42-2 2,2'-iminobis[ethanol] 
• 87-42-3 6-chloro-7H-purine 
• 87-42-3 6-chloropurine 

Relevant academic research and scientific papers

Synthesis and biological evaluation of nitrogen mustard derivatives of purine bases

This paper deals with the synthesis of nitrogen mustard analogs, derivatives of purine bases. Alkylation in position N-9 and diethanolamine fixation on position 6 were managed by microwave irradiations. Chlorination of these dihydroxylated intermediates led to a cyclization, giving tricyclic purine base analogs bearing a chloroethyl chain. Finally, MTT assays on obtained compounds do not show cytotoxicity on four different cancer cell lines.

Synthesis of novel 6-[N,N-bis(2-hydroxyethyl)amino]purine nucleosides under microwave irradiation in neat water

Novel 6-[N,N-bis(2-hydroxyethyl)amino]purine nucleosides were prepared in one step by nucleophilic substitution reaction of 6-choloropurine nucleosides with diethanolamine. Shorter reaction times and higher yields were achieved under microwave irradiation