63122-43-0

Basic information

• Product Name: 2-(furan-2-yl)-1H-pyrrole
• Synonyms: 2-(2-pyrrolyl)Furan; Furan, 2-(2-pyrrolyl)-
• CAS NO: 63122-43-0
• Molecular Formula: C₈H₇NO
• Molecular Weight: 133.1473
• Mol File: 63122-43-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 271.4°C at 760 mmHg
• Flash Point: 126.2°C
• Density: 1.149g/cm³
• Vapor Pressure: 0.0107mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: 2-(furan-2-yl)-1H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(furan-2-yl)-1H-pyrrole(63122-43-0)
• EPA Substance Registry System: 2-(furan-2-yl)-1H-pyrrole(63122-43-0)

Safety Data

• Hazardous Substances Data: 63122-43-0(Hazardous Substances Data)

Usage

General Description

2-(furan-2-yl)-1H-pyrrole, also known as furanopyrrole, is a chemical compound with a molecular formula C9H7NO. It is a heterocyclic aromatic compound containing a pyrrole ring fused with a furan ring. 2-(furan-2-yl)-1H-pyrrole is commonly used in organic synthesis and pharmaceutical research as a building block for various organic compounds. It has been the subject of research for its potential medicinal properties, particularly in the field of anti-cancer and anti-inflammatory drug development. Furanopyrrole is also known for its unique electronic and optical properties, making it a valuable component in the development of organic electronic materials and optoelectronic devices.

Upstream product

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• 5007-50-1 1-(2-furyl)ethanone oxime 
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• 63122-36-1 N-allylfuran-2-carboxylic acid amide 
• 527-69-5 2-furancarbonyl chloride 
• 614-99-3 Ethyl 2-furoate 
• 85868-22-0 O-(2-vinyl) methyl 2-furyl ketoxime 
• 63122-39-4 N-allyl-furan-2-carboximidoyl chloride 
• 611-13-2 2-furoic acid methyl ester 

Relevant articles and documents

Expedient one-pot synthesis of pyrroles from ketones, hydroxylamine, and 1,2-dichloroethane

2- and 2,3-Substituted pyrroles are readily synthesized in a one-pot procedure from ketones, hydroxylamine hydrochloride, and 1,2-dichloroethane in the KOH/DMSO system (120 °C, 2-4 h), the yields of pyrroles ranging 11-85%. Aliphatic, cycloaliphatic, aromatic, and heteroaromatic ketones tolerate the reaction conditions.

The triphenyl phosphite-chlorine reagent in the synthesis of pyrroles from N-allylamides

A novel application of (PhO)3P-Cl2 chemistry to the synthesis of 2-substituted and 2,3-disubstituted pyrroles from N-allyl-amides is illustrated. A mild procedure is used to generate the imino chloride intermediates, which are subseq

A second generation synthesis of roseophilin and chromophore analogues

A concise, flexible, and high-yielding synthesis of the macrocyclic compound 4 is outlined which served as a key intermediate in a previous total synthesis of the antitumor active alkaloid roseophilin 1. The key steps of this approach consist of a Pd(0)-catalyzed reaction of vinyloxirane 6 with sulfone 7 and in a subsequent ring closing metathesis (RCM) reaction for the formation of the 13-membered ring catalyzed by the ruthenium carbene Cl2(PCy3)2Ru=CHCH=CPh2 introduced by Grubbs. Moreover, nitrile ylide cycloaddition reactions are used for the preparation of roseophilin side chain mimics. Finally, the synthesis of various chromophore analogues of 1 is reported, including deschlorodesmethoxyroseophilin 12 which is the most elaborate derivative of this complex target reported so far.