63124-55-0

Usage

Uses

1,3-Benzodioxole-5-carboxaldehyde, 2,2-dimethylis used as a chemical intermediate for the synthesis of various compounds in the chemical industry. Its unique molecular structure allows it to participate in a wide range of chemical reactions, making it a valuable component in the development of new materials and products. However, detailed information about its specific applications is not widely known or documented.

Upstream product

• 139225-41-5 C₉H₉BrMgO₂ 
• 68-12-2 N,N-dimethyl-formamide 
• 4188-73-2 bisisopropenyl ether 
• 2150-43-8 3,4-dihydroxybenzoic acid methyl ester 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 88517-56-0 2,2-dimethyl-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 67-64-1 acetone 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 71203-57-1 (2,2-dimethylbenzo[d][1,3]dioxol-5-yl)methanol 

Downstream Products

• 129841-02-7 3,4-O-isopropylidene-6-nitrobenzaldehyde 
• 73447-99-1 2,2-Dimethyl-5-hydroxybenzo[1,3]dioxole 
• 1019776-83-0 2,2-dimethylbenzo[d][1,3]dioxole-5-carbaldehyde oxime 
• 1019776-84-1 (2,2-dimethylbenzo[d][1,3]dioxol-5-yl)methanamine 
• 1154096-75-9 (Z)-methyl 2-(tert-butoxycarbonyl)-3-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)acrylate 
• 213984-37-3 N-(2,2-Dimethyl-benzo[1,3]dioxol-5-ylmethyl)-2,2,2-trifluoro-N-[2-(4-hydroxy-phenyl)-ethyl]-acetamide 

Relevant academic research and scientific papers

3- (BENZO [D] [1,3] DIOXOL-5-YLMETHYL) -4- (THIO) OXO-2- (THIO) OXO-AZOLIDIN-5-YLIDENE DERIVATIVES AS ANTIBACTERIAL AGENTS

The present invention concerns novel azolidine compounds of Formula (I) wherein X denotes S, NH, CH2 or O, Y and W denotes each independently S or O, Q denotes CH or N, n and m are an integer from 0 to 2, and R1 and R2 denote independently from each other hydrogen, optionally substituted aryl, optionally substituted heterocyclyl, or an optionally substituted (C1-10) aliphatic group, R3 denotes hydrogen, lower alkyl, halogen, lower alkoxy, nitro, and R4 and R5 denote independently from each other hydrogen, halogen or alkyl, with the proviso that if one of R1 and R2 is hydrogen then the respective other one of R1 and R2 does not denote substituted or unsubstituted 2-furyland their salts, that are useful as pharmaceutical agents, e.g. as antibacterial agents, and to pharmaceutical compositions comprising such compounds.

Oxidative Intramolecular Phenolic Coupling Reaction Induced by a Hypervalent Iodine(III) Reagent: Leading to Galanthamine-Type Amaryllidaceae Alkaloids

By extending our oxidative phenol-coupling reactions using a hypervalent iodine(III) reagent, a versatile synthetic procedure for the galanthamine-type Amaryllidaceae alkaloids was accomplished. The first total synthesis of (±)-sanguinine and the total syntheses of (±)-galanthamine, (±)- narwedine, (±)-lycoramine, and (±)-norgalanthamine were also successfully carried out.

NO-CARRIER ADDED (NCA) ARYL FLUORIDES VIA THE NUCLEOPHILIC AROMATIC SUBSTITUTION OF ELECTRON-RICH AROMATIC RINGS

Nucleophilic aromatic substitution by fluoride ion has been demonstrated on rings containing electron donating groups in addition to the necessary electron withdrawing and leaving groups.The reaction of (18)F- with a series of aromatic nitro aldehydes having protected hydroxyl substituents on the ring was studied.The reactivity of the aromatic ring towards nucleophilic substitution to give (18)F-labeled aromatic fluoroaldehyde derivatives is correlated with electron density at the reaction center.The effect of a number of protected hydroxyl substituents is reported. 13C-NMR was used as a sensitive probe for the changes in electron distribution at the ring carbon atoms.Radiochemical yield correlated with ppm values at the reaction center.This methodology has been applied to the synthesis of no-carrier-added(NCA) 6-fluoro-L-DOPA.The extension of this strategy to the syntheses of other labeled pharmaceuticals appears promising.

Preparation of 2-substituted-1,3-dioxacycloalkanes from diols and diunsaturated ethers

2-Substituted-1,3-dioxacycloalkanes (also known as acetonides) (such as STR1 (4-hydroxy-2,2-dimethyl-1,3-benzodioxole)) are prepared by reacting a diol (such as 1,2,3-trihydroxybenzene) and a diunsaturated ether (such as diisopropenyl ether). The reaction is exothermic and produces a ketone as the only by-product. The invention has utility in hydroxyl moiety "protection" and in pesticide synthesis.