63124-55-0

Basic information

• Product Name: 1,3-Benzodioxole-5-carboxaldehyde, 2,2-dimethyl-
• CAS NO: 63124-55-0
• Molecular Formula: C10H10O3
• Molecular Weight: 178.188
• Mol File: 63124-55-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,3-Benzodioxole-5-carboxaldehyde, 2,2-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Benzodioxole-5-carboxaldehyde, 2,2-dimethyl-(63124-55-0)
• EPA Substance Registry System: 1,3-Benzodioxole-5-carboxaldehyde, 2,2-dimethyl-(63124-55-0)

Safety Data

• Hazardous Substances Data: 63124-55-0(Hazardous Substances Data)

Usage

General Description

1,3-Benzodioxole-5-carboxaldehyde, 2,2-dimethyl-, also referred to as 2,2-dimethyl-1,3-benzodioxole-5-carbaldehyde, is an organic compound possessing a unique arrangement of molecules. Its molecular formula is C10H10O3. It belongs to the class of chemical compounds known as benzodioxoles, which are aromatic compounds containing a benzene ring fused to a 1,3-dioxole. 1,3-Benzodioxole-5-carboxaldehyde, 2,2-dimethyl-'s molecular structure includes an attached carboxaldehyde group, which consists of a carbonyl (C=O) and a hydroxyl (OH) group. The positioning of the "2,2-dimethyl-" in the name indicates that there are two methyl groups (CH3) attached at the 2nd position on the benzodioxole ring. It is used in various chemical reactions due to its specific structural composition, however detailed information about its specific applications are not widely known or documented.

Upstream product

• 4188-73-2 bisisopropenyl ether 
• 2150-43-8 3,4-dihydroxybenzoic acid methyl ester 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 88517-56-0 2,2-dimethyl-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 67-64-1 acetone 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 71203-57-1 (2,2-dimethylbenzo[d][1,3]dioxol-5-yl)methanol 
• 139225-41-5 C₉H₉BrMgO₂ 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1019776-83-0 2,2-dimethylbenzo[d][1,3]dioxole-5-carbaldehyde oxime 
• 213984-37-3 N-(2,2-Dimethyl-benzo[1,3]dioxol-5-ylmethyl)-2,2,2-trifluoro-N-[2-(4-hydroxy-phenyl)-ethyl]-acetamide 
• 1019776-84-1 (2,2-dimethylbenzo[d][1,3]dioxol-5-yl)methanamine 
• 1154096-75-9 (Z)-methyl 2-(tert-butoxycarbonyl)-3-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)acrylate 
• 73447-99-1 2,2-Dimethyl-5-hydroxybenzo[1,3]dioxole 
• 129841-02-7 3,4-O-isopropylidene-6-nitrobenzaldehyde 

Relevant articles and documents

3- (BENZO [D] [1,3] DIOXOL-5-YLMETHYL) -4- (THIO) OXO-2- (THIO) OXO-AZOLIDIN-5-YLIDENE DERIVATIVES AS ANTIBACTERIAL AGENTS

The present invention concerns novel azolidine compounds of Formula (I) wherein X denotes S, NH, CH2 or O, Y and W denotes each independently S or O, Q denotes CH or N, n and m are an integer from 0 to 2, and R1 and R2 denote independently from each other hydrogen, optionally substituted aryl, optionally substituted heterocyclyl, or an optionally substituted (C1-10) aliphatic group, R3 denotes hydrogen, lower alkyl, halogen, lower alkoxy, nitro, and R4 and R5 denote independently from each other hydrogen, halogen or alkyl, with the proviso that if one of R1 and R2 is hydrogen then the respective other one of R1 and R2 does not denote substituted or unsubstituted 2-furyland their salts, that are useful as pharmaceutical agents, e.g. as antibacterial agents, and to pharmaceutical compositions comprising such compounds.

NO-CARRIER ADDED (NCA) ARYL FLUORIDES VIA THE NUCLEOPHILIC AROMATIC SUBSTITUTION OF ELECTRON-RICH AROMATIC RINGS

Nucleophilic aromatic substitution by fluoride ion has been demonstrated on rings containing electron donating groups in addition to the necessary electron withdrawing and leaving groups.The reaction of (18)F- with a series of aromatic nitro aldehydes having protected hydroxyl substituents on the ring was studied.The reactivity of the aromatic ring towards nucleophilic substitution to give (18)F-labeled aromatic fluoroaldehyde derivatives is correlated with electron density at the reaction center.The effect of a number of protected hydroxyl substituents is reported. 13C-NMR was used as a sensitive probe for the changes in electron distribution at the ring carbon atoms.Radiochemical yield correlated with ppm values at the reaction center.This methodology has been applied to the synthesis of no-carrier-added(NCA) 6-fluoro-L-DOPA.The extension of this strategy to the syntheses of other labeled pharmaceuticals appears promising.