6314-58-5

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
(2E)-3-phenyl-1-pyridin-4-ylprop-2-en-1-one is used as a building block in organic synthesis and as a reagent in chemical reactions for its potential to contribute to the development of new pharmaceuticals. Its anti-inflammatory and anti-tumor properties make it a promising candidate for the creation of medications targeting various diseases and conditions.
Used in Organic Synthesis:
In the field of organic synthesis, (2E)-3-phenyl-1-pyridin-4-ylprop-2-en-1-one is utilized as a key component to construct more complex organic molecules. Its unique structure allows it to be a versatile building block, facilitating the synthesis of a wide range of compounds.
Used in the Synthesis of Heterocyclic Compounds:
(2E)-3-phenyl-1-pyridin-4-ylprop-2-en-1-one is also used in the synthesis of heterocyclic compounds, which are known for their diverse range of pharmacological applications. Its involvement in the creation of these compounds opens up opportunities for the discovery of new drugs with potential therapeutic benefits.

Upstream product

• 1122-54-9 methyl (4-pyridyl) ketone 
• 100-52-7 benzaldehyde 
• 173681-56-6 1-(4-(pyridin-2-yl)phenyl)ethanone 
• 872-85-5 pyridine-4-carbaldehyde 
• 98-86-2 acetophenone 

Downstream Products

• 1111313-01-9 C₂₈H₂₂N₂O₂ 
• 1111313-09-7 C₂₈H₂₂N₂O₂ 
• 1111313-05-3 C₂₈H₂₂N₂O₂ 
• 1355253-90-5 3-(4-chlorophenyl)-1-{5-phenyl-3-(4-pyridyl)-4,5-dihydro-1H-pyrazol-1-yl}isoquinoline 
• 19847-46-2 4-azachalcone hydrochloride 

Relevant academic research and scientific papers

High pressure-assisted low-loading asymmetric organocatalytic conjugate addition of nitroalkanes to chalcones

The application of high pressure (up to 9 kbar) allows for relatively fast (1-5 h) and highly enantioselective 1,4-addition of nitromethane and 2-nitropropane to chalcones at room temperature with substantial reduction of catalyst loading (0.2-1 mol% of cinchona alkaloid-based thioureas and squaramides). Various γ-nitroketones were obtained at 9 kbar with high yield and enantioselectivity (up to 98%), whereas in control experiments at atmospheric pressure usually only a small amount (10%) of products were formed after 20 h.

Synthesis of some new Pyridine-based Heterocyclic Compounds with Anticipated Antitumor Activity

A novel class of 5-amino-N′-(1-(pyridin-4-yl)ethylidene)-1H-pyrazole-4-carbohydrazides and 8-(pyridin-4-yl)pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones was synthesized from reaction of 2-cyano-N′-(1-(pyridin-4-yl)ethylidene)-acetohydrazide and

A regioselective and convenient one-pot multicomponent synthesis of 9-amino-3,5-diaryl-4,9-dihydro-5H-[1,2,4]triazolo[5,1-c][1,2,4]triazepine-8-thiol

An efficient and environment-friendly procedure for the synthesis of a new series of nitrogen bridge-head [1,2,4]triazolo[5,1-c][1,2,4]triazepine derivatives through one-pot three-component reaction of polyfunctional triazole with aromatic aldehydes and acetophenone derivatives using alcoholic sodium hydroxide solution. The same new products were prepared in classical route through reaction of triazole with the corresponding chalcones under the same conditions.

EGFR/HER-2 inhibitors: Synthesis, biological evaluation and 3D-QSAR analysis of dihydropyridine-containing thiazolinone derivatives

A series of dihydropyridine containing thiazolinone derivatives (4a-4r) have been designed, synthesized and their biological activities evaluated as potential EGFR and HER-2 kinase inhibitors and in tumor cell antiproliferation. The synthesized compounds

Iron-oxide nanoparticles mediated cyclization of 3-(4-chlorophenyl)-1- hydrazinylisoquinoline to 1-(4,5-dihydropyrazol-1-yl)isoquinolines

Iron-oxide nanoparticles were obtained using chitosan templates and their crystalline character and particle size have been confirmed through powder x-ray diffraction and transmission electron microscopy measurements. The particle sizes were found to be 10-25 nm. The diversified chalcones 2 were reacted with 1-hydrazinylisoquinoline 1 in the presence of iron-oxide nanoparticles to the corresponding pyrazolines 3a-j in high yield and purity. The pyrazolines were characterized by spectroscopic techniques. Springer Science+Business Media B.V. 2011.

Claisen-schmidt condensation catalyzed by metal-organic frameworks

Metal-organic framework [Fe(BTC) (BTC = 1,3,5-benzenetricarboxylic acid)] is a convenient heterogeneous catalyst for the carbon-carbon bond forming reaction in toluene between acetophenone and benzaldehyde to give selectively chalcone in high yield. Fe(BTC) appears as a general catalyst able to synthesize selectively different chalcone derivatives bearing various functionalities. Fe(BTC) could be recycled with no significant loss of catalytic efficiency and crystallinity in subsequent runs.

Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents

A series of 2,4,6-trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds showed MIC in the range of 0.25-2 μg/mL. These compounds are