63140-93-2

Basic information

• Product Name: 1-aMino-2-phenylcyclopropanecarboxylic acid
• Synonyms: 1-aMino-2-phenylcyclopropanecarboxylic acid
• CAS NO: 63140-93-2
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.19984
• EINECS: -0
• Mol File: 63140-93-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-aMino-2-phenylcyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-aMino-2-phenylcyclopropanecarboxylic acid(63140-93-2)
• EPA Substance Registry System: 1-aMino-2-phenylcyclopropanecarboxylic acid(63140-93-2)

Safety Data

• Hazardous Substances Data: 63140-93-2(Hazardous Substances Data)

Usage

Structure

Cyclopropane derivative with an amino group and a phenyl group attached to the cyclopropane ring

Pharmaceutical applications

Acts as a ligand for various receptors and enzymes

Biological activity

Modulator of the GABA receptor

Potential use

Treatment of anxiety and other central nervous system disorders

Research focus

Building block for the synthesis of novel chemical compounds with potential medicinal properties

Upstream product

• 86557-47-3 (Z)-4-benzylidene-2-benzylthio-5(4H)-thiazolone 
• 70315-54-7 methyl 1-benzamido-2-phenyl-cyclopropanecarboxylate 
• 4525-04-6 (Z)-(1,5-diphenyl)-7-oxo-6-oxa-4-azaspiro<2.4>hept-4-ene 
• 87378-79-8 methyl (Z)-1-<1-(N-imidazolyl)benzylideneamino>-2-phenylcyclopropanecarboxylate 
• 130740-31-7 Methyl (Z)-N-(Diphenylmethylene)-α,β-didehydro-β-phenylalaninate 
• 908094-04-2 phenyldiazomethane 
• 63140-84-1 (Z)-5-benzylthio-1-phenyl-7-oxo-6-thia-4-azaspiro<2.4>hept-4-ene 
• 82112-04-7 Cyclopropyl-Z-phenylalanine methyl ester hydrochloride 
• 87429-77-4 3-Azido-4-phenyl-4,5-dihydro-3H-pyrazole-3-carboxylic acid ethyl ester 
• 87429-78-5 Ethyl 1-azido-2-phenylcyclopropanecarboxylate 
• 24512-96-7 ethyl (Z)-2-azido-3-phenylacrylate 
• 15732-43-1 (E)-2-phenyl-4-benzylidene-5(4H)-oxazolone 

Downstream Products

• 70315-54-7 methyl 1-benzamido-2-phenyl-cyclopropanecarboxylate 
• 4607-84-5 (Z)-1-benzamido-2-phenylcyclopropanecarboxylic acid 

Relevant articles and documents

USP30 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of USP30, and the treatment of USP30-mediated disorders.

1-Aminocyclopropane-1-carboxylic acid derivatives: A new, general synthesis and NMDA receptor complex binding affinity study

A new synthesis of 1-aminocyclopropane-1-carboxylic acid and of its (E)- and (Z)-2-substituted analogues (R = CH3;i-Pr;C6H5) has been performed by means of the 'diazo-addition' method, starting from N-(diphenylmethylene)-2,3-dehydro-1-amino-1-carboxylate precursors. The (E)- and (Z)-2-phenyl and the (Z)-2-methylcyclopropaneamino acids have been obtained with high diastereospecificity. All the cyclopropaneamino acids prepared were tested for their affinity for some glutamate receptors and resulted inactive, wich the exception of compounds (E)-1b and (Z)-1c which showed a shallow displacement of [H]-glycine binding.

SYNTHESIS OF 1-AZIDOCYCLOPROPANECARBOXYLATES FROM 2-AZIDO-2-ALKENOATES

Addition of diazomethane to 2-azido-2-alkenoates followed by pyrolysis of the resulting pyrazoline derivatives affords the title compounds.