631863-36-0Relevant academic research and scientific papers
N-OXIDES OF DIARYLUREA DERIVATIVES AND THEIR USE AS CHK1 INHIBITORS FOR THE TREATMENT OF CANCER
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Page/Page column 53, (2008/06/13)
The invention provides a Chk-1 kinase inhibiting compound of the formula (I) or a salt, solvate or tautomer thereof, wherein: G is CH2, O, NH, NHCO or CONH; A is a group (CH2)n where n is 1 to 4 provided that when G is O or NH, n is at least 2; X1 is nitrogen or CH; X2 is nitrogen or a group CR5; X3 is nitrogen or a group CR5; X4 is nitrogen or CH; provided that no more than two of X2, X3 and X4 are nitrogen; and R1; R2; R3; R4;R5 and R6 are as defined in the claims.
Chk-1 inhibitors
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, (2008/06/13)
Disclosed are novel inhibitors of Chk-1 and methods of using the same for therapy.
DIARYLUREA COMPOUNDS AND DERIVATIVES AS CHK-1 INHIBITORS FOR THE TREATMENT OF CANCER
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Page 41, (2010/11/30)
Disclosed are novel inhibitors of Chk-1 and methods of using the same for therapy.
