6319-47-7

Basic information

• Product Name: 5-(2-Thienylmethylene)-2-thioxothiazolidine-4-one
• Synonyms: 5-(2-Thenylidene)-2-thioxothiazolidin-4-one;5-(2-Thienylidene)rhodanine;5-(2-Thienylmethylene)-2-thioxothiazolidine-4-one
• CAS NO: 6319-47-7
• Molecular Formula: C₈H₅NOS₃
• Molecular Weight: 227.3264
• Mol File: 6319-47-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 375.6°Cat760mmHg
• Flash Point: 181°C
• Appearance: /
• Density: 1.57g/cm³
• Vapor Pressure: 7.66E-06mmHg at 25°C
• Refractive Index: 1.768
• CAS DataBase Reference: 5-(2-Thienylmethylene)-2-thioxothiazolidine-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-Thienylmethylene)-2-thioxothiazolidine-4-one(6319-47-7)
• EPA Substance Registry System: 5-(2-Thienylmethylene)-2-thioxothiazolidine-4-one(6319-47-7)

Safety Data

• Hazardous Substances Data: 6319-47-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H5NOS3/c10-7-6(13-8(11)9-7)4-5-2-1-3-12-5/h1-4H,(H,9,10,11)/b6-4+

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 141-84-4 2-thioxo-4-thiazolidinone 

Downstream Products

• 89677-36-1 3-thiophen-2-yl-2-thioxo-propionic acid 
• 93203-52-2 2-(piperidin-1-yl)-5-(thiophen-2-ylmethylene)thiazol-4(5H)-one 
• 2021-58-1 rac-3-(2-thienyl)alanine 
• 4461-29-4 2-(thiophen-2-yl)acetamide 
• 1918-77-0 Thiophene-2-acetic acid 
• 30433-91-1 [2-(2-thyenyl)ethyl]amine 
• 20893-30-5 2-cyanomethylthiophene 
• 65562-31-4 3-(tetra-O-acetyl-β-D-glucopyranosyl)-5-thiophen-2-ylmethylene-2-thioxo-thiazolidin-4-one 
• 1723-27-9 thieno[3,2-b]thiophene-2-carboxylic acid 

Relevant articles and documents

Synthesis, biological evaluation, and molecular docking study of thiophene-, piperazine-, and thiazolidinone-based hybrids as potential antimicrobial agents

Antibiotic resistance in bacteria exacerbates the issue of antimicrobial resistance. Bacteria that cause common or serious infections have evolved resistance to every new antibiotic that has been introduced into the market, to varying degrees, over severa

Urea/thiourea catalyzed, solvent-free synthesis of 5-arylidenethiazolidine- 2,4-diones and 5-arylidene-2-thioxothiazolidin-4-ones

An efficient and organo-catalyzed method has been developed for the synthesis of 5-arylidenethiazolidine-2,4-diones and 5-arylidene-2- thioxothiazolidin-4-ones via Knoevenagel condensation of arylaldehydes 1 and 2,4-thiazolidinedione 2a/2-thioxothiazolidin-4-one 2b under mild conditions. Urea-adduct 4 and azomethine 5 also afford arylidene-products 3 by reacting with 2a-b via addition-elimination reaction. This protocol has the features of use of inexpensive, ecofriendly readily available, effective catalyst system viz. urea/thiourea, avoidance of volatile solvents, excellent yield and simple work-up procedure.

Orally absorbable cephalosporin antibiotics. 2. Structure-activity studies of bicyclic glycine derivatives of 7-aminodeacetoxycephalosporanic acid.

Three positional analogues (4-, 5-, and 7-) of benzothienylglycine and (N-acetylindolinyl)-5-glycine were prepared and coupled to 7-aminodeacetoxycephalosporanic acid (7-ADCA) to give the cephalosporins 17a-c. In addition two isomeric (2,3-b and 3,2-b) th