63196-12-3Relevant academic research and scientific papers
Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
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, (2008/06/13)
This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of the formula: or a pharmaceutically acceptable salt, hydrate, prodrug, or mixtures thereof, wherein Y is alkylhalo, alkyl-CO—G, COG, a direct bond, C═O, O, NR11, or CR8; G is NR11R16, OR9, SR9, or R10; Z is O, S, or NR11; X is NR16, O, S, CR12R13, C═O, a bond, —CR12═CR13—, —C(R12R13)C(R14R15)—, or; Rhd 1, R2, R3, R4, R5, R6, R7, R8, R10, R12, R13, R14, or R15are independently: hydrogen, halo, alkylhalo, hydroxy, C1-C9straight or branched chain alkyl, C2-C9straight or branched chain alkenyl group, C3-C8cycloalkyl, C5-C7cycloalkenyl, aryl, amino, alkylamino, nitro, nitroso, carboxy, or aralkyl; R9is hydrogen, hydroxy, C1-C9straight or branched chain alkyl, C2-C9straight or branched chain alkenyl group, C3-C8cycloalkyl, C5-C7cycloalkenyl, aryl, amino, alkylamino, carboxy, or aralkyl; R11or R16are independently: hydrogen, halo, alkylhalo, hydroxy, C1-C9straight or branched chain alkyl, C2-C9straight or branched chain alkenyl group, C3-C8cycloalkyl, C5-C7cycloalkenyl, aryl, amino, alkylamino, carboxy, or aralkyl.
Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
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, (2008/06/13)
This invention relates to compounds, pharmaceutical compositions, and methods for the treatment or prevention of neural or cardiovascular tissue damage related to cerebral ischemia and reperfusion injury in an animal by administering Poly(ADP-ribose) polymerase (“PARP”) inhibitors.
