6320-16-7

Basic information

• Product Name: 2-chloro-N-(2-hydroxyethyl)acetamide
• Synonyms: 2-chloro-N-(2-hydroxyethyl)acetamide;N-(2-Hydroxyethyl)-2-chloroacetamide;Acetamide, 2-chloro-N-(2-hydroxyethyl)-;Chloro-N-(2-hydroxyethyl)acetamide;Einecs 228-670-1;N-Chloroacetyl-2-aminoethanol;Nsc 31813
• CAS NO: 6320-16-7
• Molecular Formula: C₄H₈ClNO₂
• Molecular Weight: 137.56482
• EINECS: 228-670-1
• Mol File: 6320-16-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 368.2°C at 760 mmHg
• Flash Point: 176.5°C
• Appearance: /
• Density: 1.257g/cm³
• Vapor Pressure: 6.45E-07mmHg at 25°C
• Refractive Index: 1.471
• PKA: 13.35±0.46(Predicted)
• CAS DataBase Reference: 2-chloro-N-(2-hydroxyethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-(2-hydroxyethyl)acetamide(6320-16-7)
• EPA Substance Registry System: 2-chloro-N-(2-hydroxyethyl)acetamide(6320-16-7)

Safety Data

• Hazardous Substances Data: 6320-16-7(Hazardous Substances Data)

Usage

General Description

2-chloro-N-(2-hydroxyethyl)acetamide is a chemical compound with the molecular formula C4H8ClNO2. It is an organic compound that contains a chlorine atom, an acetamide group, and a hydroxyethyl group. 2-chloro-N-(2-hydroxyethyl)acetamide is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block for the production of other organic compounds. 2-chloro-N-(2-hydroxyethyl)acetamide is a white crystalline solid that is soluble in water and organic solvents. It is important to handle this compound with caution as it may be harmful if ingested, inhaled, or absorbed through the skin.

InChI:InChI=1/C4H8ClNO2/c5-3-4(8)6-1-2-7/h7H,1-3H2,(H,6,8)

Upstream product

• 141-43-5 ethanolamine 
• 96-34-4 methyl chloroacetate 
• 105-39-5 chloroacetic acid ethyl ester 
• 79-04-9 chloroacetyl chloride 
• 15018-06-1 chloroacetyl bromide 

Downstream Products

• 6272-74-8 1-[(2-dodecanoyloxyethylcarbamoyl)methyl]pyridinium chloride 
• 13627-28-6 (N-2-chloroethyl)-2-chloroacetamide 
• 109-11-5 morpholine-3-one 

Relevant articles and documents

PROCESS FOR PREPARATION OF VORTIOXETINE HYDROBROMIDE

The present invention provides a process for preparation of Vortioxetine hydrobromide (I). The present invention also relates to the novel intermediate and its use in preparation of vortioxetine hydrobromide (I).

Bifunctional ligands based on the DOTA-monoamide cage

Efficient routes to DOTA-monoamide ligands bearing amino, hydroxyl, aldehyde and maleimido groups are described. These functional groups, which can be spaced at will from the coordination cage, will readily react with suitable groups of targeting moieties

Synthesis, spectral studies and anti-inflammatory activity of glycolamide esters of niflumic acid as potential prodrugs

In order to reduce the gastric irritation caused by direct contract mechanism of the carboxylic acid group, a series of glycolamide esters of niflumic (CAS 4394-00-7) (1) have been prepared as biolabile prodrugs by reacting appropriate 2-chloroacetamides with niflumic acid. The required 2-chloroacetamides were obtained by the condensation of chloroacetyl chloride and corresponding amine. Their structures were confirmed by UV, IR and 1H NMR spectra. Selected compounds were evaluated for anti-inflammatory activity in carrageenan induced paw oedema in rats at the doses of 45, 90 and 150 mg/kg b.w. Prodrugs showed comparable anti-inflammatory activity (67.1-79.4%) at 150 mg/kg b.w. with respect to niflumic acid (70.3%) at 45 mg/kg b.w., indicating moderate release of niflumic acid in vivo. The highest activity was observed with diethylamine (4) and pyrrolidine (9) derivatives.