63218-45-1

Upstream product

• 94-99-5 2,4-Dichlorobenzyl chloride 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 141-97-9 ethyl acetoacetate 
• 6186-89-6 ethyl methyl malonate 

Downstream Products

• 83259-54-5 3-benzenesufonyloxy-4-(2,4-dichlorobenzyl)-5-methyl-isoxazole 
• 107427-40-7 benzenesufonyloxy-4-(2,4-dichlorobenzyl)-5-methylisoxazole 
• 107427-39-4 3-benzenesufonyloxy-4-(2,4-dichlorobenzyl-α-hydroxybenzyl)-5-methylisoxazole 
• 107427-38-3 Benzenesulfonic acid 4-[bromo-(2,4-dichloro-phenyl)-methyl]-5-methyl-isoxazol-3-yl ester 
• 1453097-33-0 C₁₈H₁₄Cl₂N₄O 
• 1398179-91-3 ethyl 2-diazo-3-(2,4-dichlorophenyl)propanoate 
• 932708-75-3 2-(2,4-dichlorobenzyl)-N-(2-fluoro-5-hydroxyphenyl)-3-oxobutyramide 
• 702638-19-5 4-(2,4-dichloro-benzyl)-5-methyl-1H-pyrazol-3-ol 

Relevant academic research and scientific papers

Copper-mediated trifluoromethylation of α-diazo esters with TMSCF3: The important role of water as a promoter

Copper-mediated trifluoromethylation of α-diazo esters with TMSCF3 reagent has been developed as a new method to prepare α-trifluoromethyl esters. This trifluoromethylation reaction represents the first example of fluoroalkylation of a non-fluorinated carbene precursor. Water plays an important role in promoting the reaction by activating the "CuCF3" species prepared from CuI/TMSCF3/CsF (1.0:1.1:1.1). The scope of this trifluoromethylation reaction is broad, and its efficiency is demonstrated in the synthesis of a variety of aryl-, benzyl-, and alkyl-substituted 3,3,3-trifluoropropanoates.

Synthesis of 3-Hydroxyisoxazoles from β-Ketoesters and Hydroxylamine

An efficient synthesis of 3-hydroxyisoxazoles from β-ketoesters and hydroxylamine was investigated.The reaction of the sodium salts of β-ketoesters and hydroxylamine at a low temperature, followed by quenching with an excess of conc.HCl under heating gave predominantly 3-hydroxyisoxazoles involving 4-sulfenylated 3-hydroxyisoxazoles.Starting from the prepared 4-(2,4-dichlorobenzyl)-3-hydroxy-5-methylisoxazole, a potential herbicidal compound, 4-(2,4-dichlorobenzoyl)-3-hydroxy-5-methylisoxazole, was also synthesized in five steps.