83259-54-5

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 83259-53-4 4-(2,4-dichlorobenzyl)-3-hydroxy-5-methylisoxazole 
• 94-99-5 2,4-Dichlorobenzyl chloride 
• 63218-45-1 ethyl 2-(2,4-dichlorobenzyl)acetoacetate 

Downstream Products

• 107427-38-3 Benzenesulfonic acid 4-[bromo-(2,4-dichloro-phenyl)-methyl]-5-methyl-isoxazol-3-yl ester 
• 107427-40-7 benzenesufonyloxy-4-(2,4-dichlorobenzyl)-5-methylisoxazole 
• 107427-39-4 3-benzenesufonyloxy-4-(2,4-dichlorobenzyl-α-hydroxybenzyl)-5-methylisoxazole 

Relevant academic research and scientific papers

Synthesis of 3-Hydroxyisoxazoles from β-Ketoesters and Hydroxylamine

An efficient synthesis of 3-hydroxyisoxazoles from β-ketoesters and hydroxylamine was investigated.The reaction of the sodium salts of β-ketoesters and hydroxylamine at a low temperature, followed by quenching with an excess of conc.HCl under heating gave predominantly 3-hydroxyisoxazoles involving 4-sulfenylated 3-hydroxyisoxazoles.Starting from the prepared 4-(2,4-dichlorobenzyl)-3-hydroxy-5-methylisoxazole, a potential herbicidal compound, 4-(2,4-dichlorobenzoyl)-3-hydroxy-5-methylisoxazole, was also synthesized in five steps.