6322-62-9

Basic information

• Product Name: 3-(thiophen-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one
• Synonyms: 3-(2-thienylmethyl)-2-thioxo-1,3-thiazolan-4-one
• CAS NO: 6322-62-9
• Molecular Formula: C₈H₇NOS₃
• Molecular Weight: 229.3423
• Mol File: 6322-62-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 360°C at 760 mmHg
• Flash Point: 171.5°C
• Density: 1.52g/cm³
• Vapor Pressure: 2.29E-05mmHg at 25°C
• Refractive Index: 1.739
• CAS DataBase Reference: 3-(thiophen-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(thiophen-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one(6322-62-9)
• EPA Substance Registry System: 3-(thiophen-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one(6322-62-9)

Safety Data

• Hazardous Substances Data: 6322-62-9(Hazardous Substances Data)

Upstream product

• 27757-85-3 2-Aminomethylthiophene 
• 75-15-0 carbon disulfide 
• 13558-70-8 methyl N-(chloroacetyl)carbamate 
• 6326-83-6 bis(carboxymethyl)trithiocarbonate 

Downstream Products

• 1370635-04-3 (Z)-5-(2-(5-chloro-1H-indol-3-yl)-2-oxoethylidene)-3-(thiophen-2-ylmethyl)-2-thioxothiazolidin-4-one 

Relevant articles and documents

A concise approach to n-substituted rhodanines through a base-assisted one-pot coupling and cyclization process

An efficient approach to obtain functionalized rhodanines was developed through a base-assisted one-pot coupling and continuous cyclization of a primary amine, carbon disulfide, and methyl (2-chloroacetyl)carbamate. This conversion tolerates a broad range of functional groups and can be used to scale the preparation of N-substituted rhodanines in excellent yields.

A facile synthesis of novel 3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin- 4-ones using microwave heating

(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-(aryl/alkyl-2-ylmethyl) -2-thioxothiazolidin-4-ones (7a-w) have been synthesized by the Knoevenagel condensation reaction of 3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin-4-ones (3a-d) with suitably substituted 2-(1H-indol-3-yl)2-oxoacetaldehydes (6a-g) under microwave conditions. The thioxothiazolidin-4-ones were prepared from the corresponding aryl/alkyl amines (1a-d) and di-(carboxymethyl)-trithiocarbonyl (2). The aldehydes (6a-g) were synthesized from the corresponding acid chlorides (5a-g) using HsnBu3.

Phospholipase D inhibitors and uses thereof

The invention is directed to thiazolidinones and the use thereof to inhibit phospholipase D (PLD) activity. The invention further relates to methods of treating cancer and inflammatory diseases using thiazolidinones.