632322-78-2Relevant academic research and scientific papers
A radical cyclisation based cyclopentenone annulation of allyl alcohols
Srikrishna,Viswajanani,Sattigeri
, p. 2975 - 2983 (2003)
A four-step cyclopentenone annulation reaction of allylic alcohols employing a 5-exo-trig radical cyclisation reaction of mixed allyl methyl ketals of bromoacetone as the key step is described. The annulated product 12b obtained from 2,3-dimethylcyclohexenol has been further elaborated into (±)-epibakkenolides employing a 5-exo-dig radical cylisation reaction based α-spiro-β-methylene-γ-butyrolactone annulation methodology.
Cyclopentaannulation of Allyl Alcohols via a Radical Cyclisation Reaction. Total Synthesis of 4-Epibakkenolide-A
Srikrishna, A.,Viswajanani, R.,Sattigeri, J. A.
, p. 469 - 470 (2007/10/02)
A four step cyclopentaannulation methodology starting from allyl alcohols using 5-exo-trig radical cyclisation as the key reaction, and its application to the total synthesis of 4-epibakkenolide is described.
