632335-02-5 Usage
Description
1-(4-Fluoro-phenyl)-isoquinoline is a chemical compound characterized by the molecular formula C17H11FN. It is an isoquinoline derivative featuring a substituted fluorophenyl group attached to the isoquinoline ring. 1-(4-Fluoro-phenyl)-isoquinoline holds promise in the realm of medicinal chemistry and drug development due to its unique structural attributes and potential biological activities. The specific properties and applications of 1-(4-Fluoro-phenyl)-isoquinoline can vary based on the synthesis method and the intended use, which makes it a significant subject of interest for researchers and scientists across different fields.
Uses
Used in Medicinal Chemistry:
1-(4-Fluoro-phenyl)-isoquinoline is utilized as a key intermediate in the synthesis of various pharmaceutical compounds for its unique structural features that can influence biological activity. Its presence in a molecule can modulate interactions with biological targets, potentially leading to the development of new therapeutic agents.
Used in Drug Development:
In the pharmaceutical industry, 1-(4-Fluoro-phenyl)-isoquinoline serves as a building block for designing and optimizing drug candidates. Its incorporation into drug molecules can enhance pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, as well as pharmacodynamic effects, including potency and selectivity at the molecular level.
Used in Research and Development:
1-(4-Fluoro-phenyl)-isoquinoline is employed as a research tool in academic and industrial laboratories. Scientists use this compound to investigate its potential biological activities, such as its interaction with specific receptors or enzymes, which can provide insights into the development of novel therapeutic strategies for various diseases.
Used in Chemical Synthesis:
As a versatile chemical entity, 1-(4-Fluoro-phenyl)-isoquinoline is used in the synthesis of a range of organic compounds, including complex organic molecules and functional materials. Its reactivity and structural characteristics make it a valuable component in the creation of new chemical entities with tailored properties for specific applications.
Check Digit Verification of cas no
The CAS Registry Mumber 632335-02-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,3,2,3,3 and 5 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 632335-02:
(8*6)+(7*3)+(6*2)+(5*3)+(4*3)+(3*5)+(2*0)+(1*2)=125
125 % 10 = 5
So 632335-02-5 is a valid CAS Registry Number.
632335-02-5Relevant articles and documents
Synthesis and photophysical studies of iridium complexes of fluorinated phenylisoquinolines
Rho, Hyeon Hee,Park, Yong Hwan,Lee, Young Hee,Park, No Gill,Ha, Yunkyoung,Kim, Young Sik
, p. 145 - 155 (2006)
There have been reported materials emitting green color in both fluorescence and phosphorescence with great success, however efficient red luminescence materials are rare. Recently, it has been reported iridium (III) complexes of 1-(phenyl)isoquinoline (
Cyclometalated Ru(II)-isoquinoline complexes overcome cisplatin resistance of A549/DDP cells by downregulation of Nrf2 via Akt/GSK-3β/Fyn pathway
Chen, Lanmei,Wang, Jie,Cai, Xianhong,Chen, Suxiang,Zhang, Jingjing,Li, Baojun,Chen, Weigang,Guo, Xinhua,Luo, Hui,Chen, Jincan
, (2021/12/04)
Both ruthenium (Ru) and isoquinoline (IQ) compounds are regarded as potential anticancer drug candidates. Here, we report the synthesis and characterization of three novel cyclometalated Ru(II)-isoquinoline complexes: RuIQ-3, RuIQ-4, and RuIQ-5, and evalu
Iron catalyzed oxidative assembly of N-heteroaryl and aryl metal reagents using oxygen as an oxidant
Liu, Kun Ming,Liao, Lian Yan,Duan, Xin Fang
supporting information, p. 1124 - 1127 (2015/01/09)
An equivalent amount of N-heteroaryl and aryl Grignard or lithium reagents, after mediation by an equivalent of titanate, was facilely coupled to furnish N-heteroaryl-aryl compounds under the catalysis of FeCl3/TMEDA at ambient temperature using oxygen as an oxidant. Most of the common N-heteroaryls were all good candidates, and thus provided a general, green and pratical protocol for the flexible construction of various N-heteroaryl-aryl structures. This journal is
Iron-catalyzed cross-coupling of N-heterocyclic chlorides and bromides with arylmagnesium reagents
Kuzmina, Olesya M.,Steib, Andreas K.,Knochel, Paul,Flubacher, Dietmar
supporting information, p. 4818 - 4821,4 (2012/12/12)
A simple, practical iron salt catalyzed procedure allows fast cross-couplings of N-heterocyclic chlorides and bromides with various electron-rich and -poor arylmagnesium reagents. A solvent mixture of THF and tBuOMe is found to be essential for achieving high yields mainly by avoiding homocoupling side reactions.
