632335-02-5

Usage

Uses

Used in Medicinal Chemistry:
1-(4-Fluoro-phenyl)-isoquinoline is utilized as a key intermediate in the synthesis of various pharmaceutical compounds for its unique structural features that can influence biological activity. Its presence in a molecule can modulate interactions with biological targets, potentially leading to the development of new therapeutic agents.
Used in Drug Development:
In the pharmaceutical industry, 1-(4-Fluoro-phenyl)-isoquinoline serves as a building block for designing and optimizing drug candidates. Its incorporation into drug molecules can enhance pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, as well as pharmacodynamic effects, including potency and selectivity at the molecular level.
Used in Research and Development:
1-(4-Fluoro-phenyl)-isoquinoline is employed as a research tool in academic and industrial laboratories. Scientists use 1-(4-Fluoro-phenyl)-isoquinoline to investigate its potential biological activities, such as its interaction with specific receptors or enzymes, which can provide insights into the development of novel therapeutic strategies for various diseases.
Used in Chemical Synthesis:
As a versatile chemical entity, 1-(4-Fluoro-phenyl)-isoquinoline is used in the synthesis of a range of organic compounds, including complex organic molecules and functional materials. Its reactivity and structural characteristics make it a valuable component in the creation of new chemical entities with tailored properties for specific applications.

Upstream product

• 64-04-0 phenethylamine 
• 5450-75-9 4-methyl-N-(2-phenylethyl)benzenesulfonamide 
• 352-34-1 4-fluoro-1-iodobenzene 
• 19493-44-8 1-chloroisoquinoline 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 1443309-02-1 C₂₆H₂₃FNO₂⁽¹⁺⁾*Br^(1-) 

Relevant academic research and scientific papers

Synthesis and photophysical studies of iridium complexes of fluorinated phenylisoquinolines

There have been reported materials emitting green color in both fluorescence and phosphorescence with great success, however efficient red luminescence materials are rare. Recently, it has been reported iridium (III) complexes of 1-(phenyl)isoquinoline (

Synthesis and photophysical studies of heteroleptic tris-cyclometalated Ir(III) complex for red OLED

The synthesis and photophysical study of efficient phosphorescent iridium(III) complex having two different (CN) ligands are reported. In order to improve the luminescence efficiency by avoiding triplet-triplet (T-T) annihilation and study luminescent mec

Cyclometalated Ru(II)-isoquinoline complexes overcome cisplatin resistance of A549/DDP cells by downregulation of Nrf2 via Akt/GSK-3β/Fyn pathway

Both ruthenium (Ru) and isoquinoline (IQ) compounds are regarded as potential anticancer drug candidates. Here, we report the synthesis and characterization of three novel cyclometalated Ru(II)-isoquinoline complexes: RuIQ-3, RuIQ-4, and RuIQ-5, and evalu

Orange-Red Phosphorescent Iridium(III) Complexes Bearing Bisphosphine Ligands: Synthesis, Photophysical and Electrochemical Properties, and DFT Calculations

Nine new phosphorus-coordinated iridium(III) complexes of the form [Ir(C^N)2(P^P)]PF6, [Ir(F-piq)2(xantphos)]PF6 (1), [Ir(F-piq)2(binap)]PF6 (2), [Ir(F-piq)2/sub

Iron catalyzed oxidative assembly of N-heteroaryl and aryl metal reagents using oxygen as an oxidant

An equivalent amount of N-heteroaryl and aryl Grignard or lithium reagents, after mediation by an equivalent of titanate, was facilely coupled to furnish N-heteroaryl-aryl compounds under the catalysis of FeCl3/TMEDA at ambient temperature using oxygen as an oxidant. Most of the common N-heteroaryls were all good candidates, and thus provided a general, green and pratical protocol for the flexible construction of various N-heteroaryl-aryl structures. This journal is

Unprecedented combination of regioselective hydrodefluorination and ligand exchange reaction during the syntheses of tris-cyclometalated iridium(iii) complexes

The first reported combination of regioselective hydro-defluorination and a ligand exchange reaction during the syntheses of neutral iridium(iii) complexes is presented. Surprisingly, loss of one fluorine atom per ligand combined with a complete ligand exchange reaction on the transition metal were jointly observed during a bridge-splitting and substitution reaction of two different dimeric iridium(iii) precursor complexes with two different ancillary ligands. The regioselectivity of defluorination was evidenced in both cases. The reaction time was identified as a factor strongly impacting the kinetics of the thermally induced reaction. The Royal Society of Chemistry 2013.

IRIDIUM COMPLEX COMPOUND, ORGANIC ELECTROLUMINESCENCE ELEMENT, AND USE THEREFOR

It is an object of the present invention to provide a red phosphorescent compound having a high emission quantum yield, which is used for producing organic EL elements. The red phosphorescent compound of the present invention is an iridium complex compound represented by the following formula (1). In the formula (1), L1 is selected from the following formulas (2) and (3).

Iron-catalyzed cross-coupling of N-heterocyclic chlorides and bromides with arylmagnesium reagents

A simple, practical iron salt catalyzed procedure allows fast cross-couplings of N-heterocyclic chlorides and bromides with various electron-rich and -poor arylmagnesium reagents. A solvent mixture of THF and tBuOMe is found to be essential for achieving high yields mainly by avoiding homocoupling side reactions.

Iridium complexes containing three different ligands as white OLED dopants

Previously, we studied the luminescence characteristics of Ir(ppy)2(F2-ppy) and Ir(ppy)2(piq-F), which are heteroleptic iridium complexes involving two kinds of ligands, where F2-ppy, ppy and piq-F represent 2-(2,4-difluoro-phenyl)- pyridine, 2-phenylpyri