63242-26-2

Upstream product

• 68294-33-7 4-(4-methoxy-phenyl)-benzophenone 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 124643-34-1 p-benzoylphenyl triflate 
• 5720-07-0 4-methoxyphenylboronic acid 
• 100-59-4 phenylmagnesium chloride 
• 1122-91-4 4-bromo-benzaldehyde 
• 1137-42-4 4-Hydroxybenzophenone 

Relevant academic research and scientific papers

Bench-Stable Sulfoxide-Based Boronates: Preparation and Application in a Tandem Suzuki Reaction

A set of novel aromatic and heteroaromatic bench-stable sulfoxide-based boronates was prepared. The structure of the boronates was established by means of X-ray crystallography, and the prepared boronates were successively used in Suzuki cross-coupling reactions under different conditions. We also developed a tandem Suzuki reaction so that a base is generated during the nucleophilic addition of Grignard reagents to 4-bromobenzaldehyde. The formed intermediates were smoothly coupled with the prepared boronates and the boronic acids under external base-free conditions. (Figure presented.).

Photogeneration and chemistry of biphenyl quinone methides from hydroxybiphenyl methanols

The photosolvolysis of several biphenyl methanols (Ph-PhCH[Ph]OH) substituted with hydroxy or methoxy groups on the benzene ring not containing the -CH(Ph)OH moiety has been studied in aqueous solution. This work is a continuation of our studies of photosolvolysis of hydroxy-substituted arylmethanols that generate quinone methide intermediates, some of which are known to be relevant intermediates in toxicology and in biological and organic chemistry in general. In this study, we further probe the ability of the biphenyl ring system to transmit charge from the ring substituted with a potential electron-donating group (hydroxy and methoxy) to the adjacent benzene ring that contains a labile benzyl alcohol moiety. We show that in systems with a hydroxy substituent, biphenyl quinone methides (BQM) are the first formed intermediates that are detectable by nanosecond laser flash photolysis, and are responsible for the observed overall photosolvolysis reaction of these compounds. The highly conjugated BQM are found to absorb at long wavelengths (λmax 580 and ～750 nm for the p,p′ and o,p′-isomers, respectively) with relatively long lifetimes in neutral aqueous solution (500 and 30 μs, respectively). The BQM from the o,p′-isomer was found to undergo a competing intramolecular Friedel-Crafts alkylation, to give a fluorene derivative.