63257-48-7

Upstream product

• 1056477-06-5 2-bromocyclohexanone 
• 100-52-7 benzaldehyde 
• 822-87-7 2-Chlorocyclohexanone 
• 5682-83-7 (E)-2-benzylidenecyclohexanone 
• 108-94-1 cyclohexanone 

Downstream Products

• 70388-68-0 4-(Z-Cyanmethylen)-2(E)-phenyl-1-oxaspiro<2,5>octan 
• 70388-68-0 4-(E-Cyanmethylen)-2(E)-phenyl-1-oxaspiro<2,5>octan 
• 73920-93-1 4-Methylen-2(E)-phenyl-1-oxaspiro<2,5>octan 
• 70388-69-1 4-(Z-Methoxycarbonylmethylen)-2(E)-phenyl-1-oxaspiro<2,5>octan 
• 70388-73-7 trans-2-Phenyl-2,3,4,5,6,7-hexahydrobenzofuran-3-carbonsaeure-methylester 
• 70388-73-7 cis-2-Phenyl-2,3,4,5,6,7-hexahydrobenzofuran-3-carbonsaeure-methylester 
• 70388-72-6 trans-2-Phenyl-2,3,4,5,6,7-hexahydrobenzofuran-3-carbonitril 
• 70388-72-6 cis-2-Phenyl-2,3,4,5,6,7-hexahydrobenzofuran-3-carbonitril 
• 18014-85-2 2-Phenyl-2,3,4,5,6,7-hexahydrobenzofuran 
• 100-52-7 benzaldehyde 
• 73920-94-2 4-Dicyanmethylen-2(E)-phenyl-1-oxaspiro<2,5>octan 

Relevant academic research and scientific papers

An efficient Darzens reaction promoted by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)

An efficient DBU promoted Darzens reaction utilising α-haloketones containing an enolizable α′-hydrogen is reported. This method diastereoselectively afforded the corresponding α,β-epoxy ketones good to excellent yields in an one-pot reaction without using any transition metals or additives. Furthermore, haloketones without an α′-hydrogen are also applicable in this reaction.

Stereodivergent Access to Enantioenriched Epoxy Alcohols with Three Stereogenic Centers via Ruthenium-Catalyzed Transfer Hydrogenation

The resolution technique of stereodivergent reaction on racemic mixtures (stereodivergent RRM) was employed for the first time in ruthenium complex catalyzed transfer hydrogenation of racemic epoxy ketones, providing a new and very simple method that allows access to enantioenriched epoxy alcohols with three stereogenic centers in a one-step fashion. The protocol features simple reaction conditions, practical operation, ability to scale up, and broad group tolerance.

A Novel Darzens-Type Reaction Promoted by Tributylstannylcarbamate

Stannylcarbamate 1 proved to be a selective agent for generating organotin(IV) enolates from α-halo ketones.Thus, a Darzens reaction was achieved under mild and neutral conditions.The reaction took place without any side reactions and even with aliphatic α-halo ketones bearing enolizable α'-hydrogens.Various types of α,β-epoxy ketones and esters were obtained in this one-pot reaction.The stereoselectivity of the reaction was influenced by changing the halogen substituent of the α-halo ketones and by additives.Moreover, the present method could be appliedto γ- and δ-halo ketones as enolate precursors, and five- and six-membered cyclic compounds were obtained.