63290-16-4

Upstream product

• 63290-17-5 (4-tetradecyloxyphenyl)acetic acid 
• 79-37-8 oxalyl dichloride 
• 62442-93-7 4-(tetradecyloxy)benzeneacetic acid methyl ester 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 112-71-0 1-Bromotetradecane 

Downstream Products

• 138830-25-8 N-<3-(hydroxymethyl)phenyl>-4-(tetradecyloxy)benzeneacetamide 
• 139907-02-1 N-[(2-Hydroxymethyl)phenyl]-4-(tetradecyloxy) benzeneacetamide 
• 1026447-66-4 Methanesulfonic acid 3-{acetyl-[2-(4-tetradecyloxy-phenyl)-ethyl]-amino}-benzyl ester 
• 1027044-79-6 Methanesulfonic acid 4-[2-(4-tetradecyloxy-phenyl)-acetylamino]-benzyl ester 
• 1027901-56-9 Methanesulfonic acid 3-[2-(4-tetradecyloxy-phenyl)-acetylamino]-benzyl ester 
• 1027923-00-7 Methanesulfonic acid 2-[2-(4-tetradecyloxy-phenyl)-acetylamino]-benzyl ester 
• 1027263-66-6 Acetic acid 3-{acetyl-[2-(4-tetradecyloxy-phenyl)-ethyl]-amino}-benzyl ester 
• 144767-02-2 N-(3-Hydroxymethyl-phenyl)-N-[2-(4-tetradecyloxy-phenyl)-ethyl]-acetamide 
• 138830-28-1 N-[4-(Bromomethyl)phenyl]-4-(tetradecyloxy)-benzeneacetamide 
• 138830-26-9 N-[3-(Bromomethyl)phenyl]-4-(tetradecyloxy)-benzeneacetamide 
• 139907-03-2 N-[2-(Bromomethyl)phenyl]-4-(tetradecyloxy)-benzeneacetamide 
• 138830-57-6 {3-[2-(4-Tetradecyloxy-phenyl)-ethylamino]-phenyl}-methanol 
• 138830-27-0 N-(4-Hydroxymethyl-phenyl)-2-(4-tetradecyloxy-phenyl)-acetamide 

Relevant academic research and scientific papers

Pyridinium compounds which are useful as antagonists of platelet activating factor

The invention is aryl, amide, imide and carbamate pyridine antagonists of platelet activating factor.

Analogues of platelet activating factor. 7. Bis-aryl amide and bis-aryl urea receptor antagonists of PAF

A series of bis-aryl amide (13-57 and 66-81) and bis-aryl urea (58 and 85) antagonists of platelet-activating factor (PAF) was prepared that contain, separating the two aromatic rings, linear amide linkages of the form - (CH2)(n)CONH- (n = 0-2), -OCH2CONH-, and -(CH2)(n)NHCO- (n = 0-1), branched amide linkages of the form -(CH2)(n)N(COR)- (n = 1-3, R = CH3 or n-C3H7), and -N(COCH3)CH2-, and urea linkages of the form -NHCONH- and - CH2N(CONHCH3)-. These compounds were examined for their ability to inhibit PAF-induced platelet aggregation of rabbit platelets. These in vitro data were compared to similar data obtained for a number of known PAF antagonists. The compounds were evaluated in vivo, in the mouse, for their ability to prevent death induced by a lethal challenge of PAF. The relationships between the biological activity and the nature, lipophilicity, and position of substituents of the aromatic rings were studied. Best activity was observed for compounds having linkages of the type -CH2CONH-, -CH2N(COR)-, and - CH2NHCO-. Many of these compounds inhibit PAF-induced platelet aggregation with IC50's under 1 μM.

Bis-aryl amide and urea antagonists of platelet activating factor

Bis-aryl amide and urea compounds of the general formula: STR1 wherein X is a divalent amide or urea substituent and Y is a nitrogen containing heterocycle, which compounds are inhibitors of platelet activating factor. Pharmaceutical compositions containing the compounds and methods of treating platelet activating factor associated conditions are also included.

Method of preparing bis-aryl amide and urea antagonists of platelet activating factor

Methods of preparing bis-aryl amide and urea compounds of the general formula: STR1 wherein x is a divalent amide or urea substituent and Y is a nitrogen containing heterocycle, which compounds are inhibitors of platelet activating factor.

Preparation of aryl-butadienoic acids

Aryl-butadienoic acids, e.g., 4-(p-tetradecyloxyphenyl)-2-methyl-buta-2,3-dienoic acid, are prepared by a process comprising converting an acyl halide of an aryl lower alkanoic acid to its corresponding β,β,β-trichloroethyl ester of the desired aryl-butad

Hypolipidemic allene carboxylic acids

The compounds are 4-aryl substituted buta-2,3-dienoic acids and esters thereof which may also be lower alkyl-substituted at any of the 2- and 4-positions, e.g., 4-(p-methoxyphenyl)-2-methyl-buta-2,3-dienoic acid. The compounds are useful as pharmaceutical