63296-32-2

Usage

Uses

Used in Chemical Synthesis:
Benzoic acid, 4-azido-, hydrazide is used as a chemical intermediate for the synthesis of other chemical compounds. Its unique azide and hydrazide functional groups make it a versatile building block in organic chemistry.
Used in Pharmaceutical Research:
In the field of pharmacology, benzoic acid, 4-azido-, hydrazide is used as a research compound to explore its potential therapeutic properties. Its structure and functional groups may contribute to the development of new drugs and pharmaceutical agents.
Used in Chemical Reactions:
Benzoic acid, 4-azido-, hydrazide is used as a reactant in various chemical reactions, such as click chemistry, where the azide group can participate in cycloaddition reactions with alkynes to form triazoles. This property allows for the creation of new compounds and materials with specific properties and applications.

Upstream product

• 6427-66-3 4-azidobenzoic acid 
• 150-13-0 4-amino-benzoic acid 
• 1590448-44-4 tert-butyl 2-(4-azidobenzoyl)hydrazine carboxylate 

Relevant academic research and scientific papers

Biodegradable magnetic nanocarrier for stimuli responsive drug release

Biocompatible nanocarriers conjugated with magnetic nanoparticle, doxorubicin and poly(ethylene oxide) (PEG) motif have been designed (PVLPEG-PVLDOXI-PCL-PHOS) to create a magnetic vector under magnetic field. Acylhydrazine linker is used to release the drug exactly at the mild acidic conditions resembling the pH of the cancerous cells. All the monomers and polymers are characterized carefully by the routine analytical techniques. Thermogravimetric analysis (TGA), FT-IR spectroscopy and scanning electron microscope (SEM) techniques are employed to confirm the anchoring of iron particle (Fe3O4) to the PVLPEG-PVLDOXI-PCL-PHOS. Reservoir capabilities of the newly designed biodegradable nanocarrier are tested by both dynamic light scattering (DLS) and transmission electron microscopy (TEM). Drug release profile from nanocarrier is monitored by fluorimeter. The release profile shows the importance of having the acylhydrazine linker that helps to release the drug at the mild acidic conditions similar to cancerous cells. Confocal laser scanning microscopy (CLSM) and flow cytometry studies on 4T cells indicate that nanocarriers from PVLPEG-PVLDOXI-PCL-PHOS polymer are internalized efficiently. It is very interesting to note that the nanocarriers have exhibited both biologically and magnetically targeting abilities toward 4T cells in vitro.