6330-40-1

Basic information

• Product Name: 2-(3-nitrophenyl)-2-oxo-acetic acid
• Synonyms: 2-(3-nitrophenyl)-2-oxo-acetic acid
• CAS NO: 6330-40-1
• Molecular Formula: C₈H₅NO₅
• Molecular Weight: 195.13
• Mol File: 6330-40-1.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 358.6°C at 760 mmHg
• Flash Point: 162°C
• Appearance: /
• Density: 1.531g/cm³
• Vapor Pressure: 9.13E-06mmHg at 25°C
• Refractive Index: 1.613
• PKA: 1.84±0.54(Predicted)
• CAS DataBase Reference: 2-(3-nitrophenyl)-2-oxo-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-nitrophenyl)-2-oxo-acetic acid(6330-40-1)
• EPA Substance Registry System: 2-(3-nitrophenyl)-2-oxo-acetic acid(6330-40-1)

Safety Data

• Hazardous Substances Data: 6330-40-1(Hazardous Substances Data)

Usage

Nitrophenyl derivative

2-oxo-acetic acid It is a derivative of 2-oxo-acetic acid, which has a nitrophenyl group (-C6H4NO2) attached to it.

Nitro group

-NO2 The compound contains a nitro group, which is a functional group consisting of one oxygen atom double-bonded to one nitrogen atom and a second oxygen atom single-bonded to the same nitrogen atom.

Phenyl group

-C6H5 The structure also includes a phenyl group, which is a six-membered carbon ring with five hydrogen atoms and one substituent group (in this case, the nitro group).

Organic synthesis and pharmaceutical research

Building block 2-(3-nitrophenyl)-2-oxo-acetic acid is commonly used as a building block in organic synthesis and pharmaceutical research for the synthesis of various organic compounds and pharmaceuticals.

Biological activities

Anti-inflammatory and analgesic properties The compound has been studied for its potential biological activities, including its ability to reduce inflammation and relieve pain.

Potential use in new medications

Various medical conditions 2-(3-nitrophenyl)-2-oxo-acetic acid has been investigated for its potential use in the development of new medications to treat a range of medical conditions.

InChI:InChI=1/C8H5NO5/c10-7(8(11)12)5-2-1-3-6(4-5)9(13)14/h1-4H,(H,11,12)

Upstream product

• 121-89-1 3-Nitroacetophenone 
• 114263-87-5 bromo-nitro-phenyl-acetonitrile 
• 121-90-4 m-nitrobenzoic acid chloride 
• 61017-48-9 (3-nitro-phenyl)-glyoxylonitrile 
• 7697-37-2 nitric acid 
• 611-73-4 Benzoylformic acid 
• 42164-79-4 3-nitromandelic acid 
• 89882-92-8 3-(3-nitro-benzoyloxy)-benzoic acid 
• 151-50-8 potassium cyanide 
• 89882-93-9 4-(3-nitro-benzoyloxy)-benzoic acid 
• 876494-77-8 bromo-nitro-(3-nitro-phenyl)-acetonitrile 
• 935764-13-9 2-(3-nitrophenyl)-2-oxoacetamide 
• 6890-77-3 3-nitrophenylglyoxal 

Downstream Products

• 121-92-6 3-nitrobenzoic acid 
• 1354964-60-5 (E)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(3-nitrophenyl)acetic acid 
• 1354965-25-5 (Z)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(3-nitrophenyl)acetic acid 
• 618-95-1 methyl 3-nitrobenzoate 
• 189638-16-2 2,2'-((3-nitrophenyl)methylene)bis(1H-pyrrole) 
• 16616-39-0 1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one 

Relevant articles and documents

K2S2O8mediated synthesis of 5-Aryldipyrromethanes and meso-substituted A4-Tetraarylporphyrins

The synthesis of dipyrromethanes from pyrrole and arylglyoxylic acids in the presence of K2S2O8at 90 C is reported affording dipyrromethanes in very good yields. Unlike an excess pyrrole traditionally used in dipyrromethane synthesis, the current method uses a stoichiometric amount of pyrrole avoiding any use of Br?nsted or Lewis acid. A gram scale synthesis of 5-phenyldipyrromethane is also achieved demonstrating potential scale up of dipyrromethanes using this method feasible. Subsequently, dipyrromethanes were converted to A4tetraarylporphyrins also in the presence of K2S2O8at 90C. A direct synthesis of A4-tetraphenylporphyrin from excess pyrrole and phenylglyoxylic acid in the presence of K2S2O8 at 90C is also reported.

CERTAIN PROTEIN KINASE INHIBITORS

Disclosed herein are protein kinase inhibitors, more particularly pyridazine derivatives and pharmaceutical compositions thereof, and method of use thereof.

Palladium-catalyzed decarboxylative acylation of O-methyl ketoximes with α-keto acids

A mild, practical and efficient palladium-catalyzed decarboxylative ortho-acylation of O-methyl ketoximes with α-keto acids via C-H bond activation is described. In these reactions, a broad range of O-methyl ketoximes and α-keto acids undergoes the decarboxylative cross-coupling reactions with high selectivities and good tolerance. The Royal Society of Chemistry 2013.