6330-40-1

Usage

Nitrophenyl derivative

2-oxo-acetic acid It is a derivative of 2-oxo-acetic acid, which has a nitrophenyl group (-C6H4NO2) attached to it.

Nitro group

-NO2 The compound contains a nitro group, which is a functional group consisting of one oxygen atom double-bonded to one nitrogen atom and a second oxygen atom single-bonded to the same nitrogen atom.

Phenyl group

-C6H5 The structure also includes a phenyl group, which is a six-membered carbon ring with five hydrogen atoms and one substituent group (in this case, the nitro group).

Organic synthesis and pharmaceutical research

Building block 2-(3-nitrophenyl)-2-oxo-acetic acid is commonly used as a building block in organic synthesis and pharmaceutical research for the synthesis of various organic compounds and pharmaceuticals.

Biological activities

Anti-inflammatory and analgesic properties The compound has been studied for its potential biological activities, including its ability to reduce inflammation and relieve pain.

Potential use in new medications

Various medical conditions 2-(3-nitrophenyl)-2-oxo-acetic acid has been investigated for its potential use in the development of new medications to treat a range of medical conditions.

InChI:InChI=1/C8H5NO5/c10-7(8(11)12)5-2-1-3-6(4-5)9(13)14/h1-4H,(H,11,12)

Upstream product

• 6890-77-3 3-nitrophenylglyoxal 
• 42164-79-4 3-nitromandelic acid 
• 121-89-1 3-Nitroacetophenone 
• 114263-87-5 bromo-nitro-phenyl-acetonitrile 
• 121-90-4 m-nitrobenzoic acid chloride 
• 61017-48-9 (3-nitro-phenyl)-glyoxylonitrile 
• 7697-37-2 nitric acid 
• 611-73-4 Benzoylformic acid 
• 89882-92-8 3-(3-nitro-benzoyloxy)-benzoic acid 
• 151-50-8 potassium cyanide 
• 89882-93-9 4-(3-nitro-benzoyloxy)-benzoic acid 
• 876494-77-8 bromo-nitro-(3-nitro-phenyl)-acetonitrile 
• 935764-13-9 2-(3-nitrophenyl)-2-oxoacetamide 

Downstream Products

• 77483-97-7 5-Hydroxy-6-(3-nitro-phenyl)-pyrazine-2,3-dicarbonitrile 
• 121-92-6 3-nitrobenzoic acid 
• 1354964-60-5 (E)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(3-nitrophenyl)acetic acid 
• 1354965-25-5 (Z)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(3-nitrophenyl)acetic acid 
• 1417412-42-0 (8-(methoxyimino)-5,6,7,8-tetrahydronaphthalen-1-yl)(3-nitrophenyl)methanone 
• 189638-16-2 2,2'-((3-nitrophenyl)methylene)bis(1H-pyrrole) 
• 16616-39-0 1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one 
• 618-95-1 methyl 3-nitrobenzoate 

Relevant academic research and scientific papers

K2S2O8mediated synthesis of 5-Aryldipyrromethanes and meso-substituted A4-Tetraarylporphyrins

The synthesis of dipyrromethanes from pyrrole and arylglyoxylic acids in the presence of K2S2O8at 90 C is reported affording dipyrromethanes in very good yields. Unlike an excess pyrrole traditionally used in dipyrromethane synthesis, the current method uses a stoichiometric amount of pyrrole avoiding any use of Br?nsted or Lewis acid. A gram scale synthesis of 5-phenyldipyrromethane is also achieved demonstrating potential scale up of dipyrromethanes using this method feasible. Subsequently, dipyrromethanes were converted to A4tetraarylporphyrins also in the presence of K2S2O8at 90C. A direct synthesis of A4-tetraphenylporphyrin from excess pyrrole and phenylglyoxylic acid in the presence of K2S2O8 at 90C is also reported.

Silver-catalyzed Double Decarboxylative Radical Alkynylation/Annulation of Arylpropiolic Acids with α-keto Acids: Access to Ynones and Flavones under Mild Conditions

Ynones are privileged building blocks in various organic syntheses of heterocyclic derivatives due to their multifunctional nature, and flavones are an important class of natural products with a wide range of biological activities. We describe the catalytic double decarboxylative alkynylation of arylpropiolic acids with α-keto acids. With Ag(I)/persulfate as the catalysis system, the valuable ynones bearing various substituents could be easily obtained. The introduction of hydroxyl substituent on ortho-site of α-keto acids make this strategy further applicable to the construction of flavone derivatives via heteroannulation in moderate to good yields with a similar silver-catalyzed system. The reactions proceed under relatively mild reaction conditions and tolerate a wide variety of functional groups. Control experiments indicated that both the reactions undergo radical processes. (Figure presented.).

CERTAIN PROTEIN KINASE INHIBITORS

Disclosed herein are protein kinase inhibitors, more particularly pyridazine derivatives and pharmaceutical compositions thereof, and method of use thereof.

CERTAIN PROTEIN KINASE INHIBITORS

Disclosed herein are protein kinase inhibitors,more particularly pyridazine derivatives and pharmaceutical compositions thereof,and method of use thereof.

Palladium-catalyzed decarboxylative acylation of O-methyl ketoximes with α-keto acids

A mild, practical and efficient palladium-catalyzed decarboxylative ortho-acylation of O-methyl ketoximes with α-keto acids via C-H bond activation is described. In these reactions, a broad range of O-methyl ketoximes and α-keto acids undergoes the decarboxylative cross-coupling reactions with high selectivities and good tolerance. The Royal Society of Chemistry 2013.

Pd(ii)-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C-H bond activation

A palladium-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C-H bond activation is described. This protocol provides efficient access to a range of ortho-acyl phenylacetamides, which can be easily converted to 3-isochromanone derivatives. The Royal Society of Chemistry 2013.

Palladium-catalyzed decarboxylative acylation of O-phenyl carbamates with α-oxocarboxylic acids at room temperature

A palladium-catalyzed oxidative acylation of O-phenyl carbamates with α-oxocarboxylic acids via selective aromatic C-H bond activation is described. This protocol represents the first ortho-acylation of phenol derivatives, and a catalytic amount of triflic acid additive is crucial for this transformation. Copyright

COMPOUNDS FOR THE INHIBITION OF CELLULAR PROLIFERATION

Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, (4) disorders associated with viral infections, and/or (5) non-proliferative metabolic disorders such as type II diabetes where inhibition of translation initiation is beneficial using the compounds disclosed herein.

Oxidation of some α-hydroxy acids by tetraethylammonium chlorochromate: A kinetic and mechanistic study

The oxidation of glycolic, lactic, malic, and a few substituted mandelic acids by tetraethylammonium chlorochromate (TEACC) in dimethylsulfoxide leads to the formation of corresponding oxoacids. The reaction is first order each in TEACC and hydroxy acids. Reaction is failed to induce the polymerization of acrylonitrile. The oxidation of α-deuteriomandelic acid shows the presence of a primary kinetic isotope effect (kH/kD = 5.63 at 298 K). The reaction does not exhibit the solvent isotope effect. The reaction is catalyzed by the hydrogen ions. The hydrogen ion dependence has the following form: kobs = a + b[H+ ]. Oxidation of p-methylmandelic acid has been studied in 19 different organic solvents. The solvent effect has been analyzed by using Kamlet's and Swain's multiparametric equations. A mechanism involving a hydride ion transfer via a chromate ester is proposed.

Kinetics and mechanism of the oxidation of some α-hydroxy carboxylic acids by [bis(trifluoroacetoxy)iodo]benzene

The oxidation of α-hydroxy carboxylic acids by [bis(trifluoroacetoxy) iodo]benzene (TFAIB), to the corresponding oxoacids is first order with respect to each, the hydroxy acid, TFAIB and hydrogen ions. The oxidation of α-deuteriomandelic acid (PhCDOHCO2H) exhibits the presence of a substantial primary isotope effect confirming the cleavage of the α - C - H bond in the rate-determining step. The rate of oxidation of substituted mandelic acids correlates well with Brown's σ+ values with large negative reaction constants. A mechanism involving transfer of a hydride ion from the hydroxy acid to the oxidant has been postulated.