63321-49-3Relevant academic research and scientific papers
Reactive Oxygen Species-Triggered Tunable Hydrogen Sulfide Release
Chauhan, Preeti,Jos, Swetha,Chakrapani, Harinath
supporting information, p. 3766 - 3770 (2018/07/21)
A series of carbamothioates with tunable release of H2S after activation by reactive oxygen species are reported. The half-lives of H2S release could be tuned from 24 to 203 min by varying the basicity of the amine.
4-[18F]fluorophenyl ureas via carbamate-4-nitrophenyl esters and 4-[18F]fluoroaniline
Olma, Sebastian,Ermert, Johannes,Coenen, Heinz H.
, p. 1037 - 1050 (2007/10/03)
Four different no carrier added (n.c.a.) 4-[18F]fluorophenylurea derivatives are synthesized as model compounds via two alternative routes. In both cases carbamate-4-nitrophenylesters are used as intermediates. Either n.c.a. 4-[18F]fluoroaniline reacts with carbamates of several amines, or the carbamate of n.c.a. 4-[18F]fluoroaniline is formed at first and an amine is added subsequently to yield the urea derivative. The choice of the appropriate way of reaction depends on the possibilities of precursor synthesis. The radiochemical yields reach up to 80% after 50 min of synthesis time while no radiochemical by-products can be determined. These high yields were possible due to an optimized preparation of n.c.a. 4-[18F] fluoroaniline with a radiochemical yield of up to 90%. From the various ways of its radiosynthesis, the substitution with n.c.a. [18F]fluoride on dinitrobenzene is chosen, using phosphorous acid and palladium black for reduction of the second nitro group. Copyright
A simple and efficient biphasic method for the preparation of 4-nitrophenyl N-methyl- and N-alkylcarbamates
Peterson, Matt A.,Shi, Houguang,Ke, Pucheng
, p. 3405 - 3407 (2007/10/03)
Treatment of 4-nitrophenyl chloroformate with alkylammonium hydrochloride salts and solid anhydrous Na2CO3 in either CH2Cl2 or CH3CN gave 4-nitrophenyl N-methylcarbamate and other N-alkylcarbamate ana
Synthesis of new active o-nitrophenyl carbamates
Simon, Monika,Csunderlik, Carol,Cotarca, Livius,Cǎproiu, Miron Teodor,Neda, Ion,Turoczi, Maria Cristina,Volpicelli, Raffaella
, p. 1471 - 1479 (2007/10/03)
A very high-yielding reaction of bis(o-nitrophenyl) carbonate with aliphatic amines under mild conditions has been developed. The resulting o-nitrophenyl carbamates were characterized by IR, 1H-NMR, 13C-NMR, and elemental analysis. Copyright Taylor & Francis, Inc.
Structure-reactivity relationships as probes for the inhibition mechanism of cholesterol esterase by aryl carbamates. I. Steady-state kinetics
Lin, Gialih,Lai, Cheng-Yue,Liao, Wei-Cheng,Kuo, Bing-Hong,Lu, Chun-Ping
, p. 489 - 500 (2007/10/03)
For substituted phenyl-N-butyl carbamates (1) and 4-nitrophenyl-N-substituted carbamates (2), linear relationships between values of NH proton chemical shift (δNH), pKa, and logk[OH] and Hammett substituent constant (σ) or Taft subst
Linear free energy relationships of the inhibition of pancreatic cholesterol esterase by 4-nitrophenyl-N-alkylcarbamate
Lin, Gialih,Lai, Cheng-Yue
, p. 193 - 196 (2007/10/02)
4-Nitrophenyl-N-alkylcarbamates (1) as active site-directed irreversible inhibitors of pancreatic cholesterol esterase are investigated for values of the dissociation constant (K(i)), the carbamylation constant (k2), and the bimolecular rate co
A New Convenient Method for the Synthesis of Symmetrical and Unsymmetrical N,N'-Disubstituted Ureas
Izdebski, Jan,Pawlak, Danuta
, p. 423 - 425 (2007/10/02)
A new method is described for the preparation of symmetrically and unsymmetrically disubstituted ureas by aminolysis of bis(4-nitrophenyl) carbonate.The second substitution is slower than the first one, and it is possible to isolate monosubstituted intermediates when equimolar amounts of substrates are used.The reaction of the intermediates with different amines give unsymmetrical derivatives of urea.
