63327-24-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Chlorophenyl)propionyl chloride is used as an intermediate in the synthesis of various pharmaceutical compounds for its reactivity and ability to form amide and ester linkages with other molecules.
Used in Agrochemical Industry:
2-(4-Chlorophenyl)propionyl chloride is used as a key component in the production of agrochemicals, such as herbicides and pesticides, due to its ability to create stable and effective formulations for crop protection.

Upstream product

• 25026-34-0 4-chlorophenacetyl chloride 
• 50415-70-8 methyl 2-(p-chlorophenyl)propionate 
• 1878-66-6 4-chlorophenylacetic Acid 
• 938-95-4 2-(4-Chloro-phenyl)-propionic acid 

Downstream Products

• 131691-12-8 2-(4-Chloro-phenyl)-propionic acid 2-(2-methyl-5-nitro-imidazol-1-yl)-ethyl ester 
• 672965-89-8 2-(4-chlorophenyl)prop-1-en-1-one 
• 1067187-44-3 2-(1-(4-chlorophenyl)ethyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid 
• 1067187-78-3 3-(4-chlorophenyl)-2-oxobutyl acetate 
• 1067187-77-2 1-chloro-3-(4-chlorophenyl)butan-2-one 
• 1949-63-9 2-(4-Chloro-phenyl)-N-methyl-propionamide 
• 99838-93-4 (+/-)-2-(4-chloro-phenyl)-propionic acid amide 

Relevant academic research and scientific papers

Functionalization of α-C(sp3)?H Bonds in Amides Using Radical Translocating Arylating Groups

α-C?H arylation of N-alkylamides using 2-iodoarylsulfonyl radical translocating arylating (RTA) groups is reported. The method allows the construction of α-quaternary carbon centers in amides. Various mono- and disubstituted RTA-groups are applied to the arylation of primary, secondary, and tertiary α-C(sp3)?H-bonds. These radical transformations proceed in good to excellent yields and the cascades comprise a 1,6-hydrogen atom transfer, followed by a 1,4-aryl migration with subsequent SO2 extrusion.

AZABICYCLO AND DIAZEPINE DERIVATIVES FOR TREATING OCULAR DISORDERS

The present invention provides in one aspect azabicycio and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator. Formulae (I) & (II):

Chemospecific Cyclizations of α-Carbonyl Sulfoxonium Ylides on Aryls and Heteroaryls

The functionalization of aryl and heteroaryls using α-carbonyl sulfoxonium ylides without the help of a directing group has remained so far a neglected area, despite the advantageous safety profile of sulfoxonium ylides. Described herein are the cyclizations of α-carbonyl sulfoxonium ylides onto benzenes, benzofurans and N-p-toluenesulfonyl indoles in the presence of a base in HFIP, whereas pyrroles and N-methyl indoles undergo cyclization in the presence of an iridium catalyst. Significantly, these two sets of conditions are chemospecific for each groups of substrates.

Methods and Compositions for Selectin Inhibition

The present teachings relate to novel compounds of formula I: wherein the constituent variables are as defined herein. Compounds of the present teachings can act as antagonists of the mammalian adhesion proteins known as selecting. Methods for treating or preventing selectin-mediated disorders are provided, which include administration of these compounds in a therapeutically effective amount.

Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

A short and efficient six-step synthesis of novel phenanthridin-3-one derivatives is described. The synthesis of these derivatives is highlighted by the cyclization of a suitably placed ketone side chain with a thioiminium ion. The derivatives prepared we

Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 1. Tropic and 2-phenylpropionic acid esters

Previous studies have shown that (R)-(+)-hyoscyamine has analgesic activity as a consequence of increased ACh release following antagonism of central muscarinic autoreceptors. Since the enhancement of central cholinergic transmission could be beneficial for cognitive disorders, we manipulated (R)-(+)-hyoscyamine, synthesizing several derivatives of tropic and 2-phenylpropionic acids, with the aim of obtaining drugs which are able to increase ACh release and consequently to show analgesic and nootropic activities. The results showed that several new compounds are indeed potent analgesics (with an analgesic efficacy comparable to that of morphine) and that the most potent one ((±)-19, PG9) also has remarkable cognition- enhancing properties. Our study confirmed that the mechanism of action involves ACh release even if it is still unclear whether only muscarinic autoreceptors or, also, heteroreceptors are involved.