63333-26-6Relevant academic research and scientific papers
Alkylarylamine compound and preparation method thereof
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Paragraph 0044-0052, (2021/10/27)
The invention discloses an alkylarylamine compound and preparation method thereof. The preparation method mainly comprises the following steps: dissolving an alkyl compound, a nitro compound, an acid and a photocatalyst in a solvent; carrying out an illumination reaction at room temperature; after the reaction is finished, carrying out alkali neutralization, ethyl acetate extraction and reduced-pressure distillation to remove the solvent; and carrying out column chromatography separation to obtain the alkylarylamine compound. Compared with an alkylarylamine compound which has been widely researched and reported, the alkylarylamine compound provided by the invention has the advantages of simple operation, simple steps, high atom utilization rate, stable chemical properties, low cost, easy purification and the like; and since an alkyl group is directly activated, the method can realize conversion from low-added-value chemicals to high-added-value chemicals, and provides convenience for organic synthesis chemistry and drug synthesis.
A convenient preparation of N-alkyl and N-arylamines by smiles rearrangement - Synthesis of analogues of diclofenac
Wadia,Patil
, p. 2725 - 2736 (2007/10/03)
Smiles rearrangement of substituted aryloxyacetamides in which oxygen and nitrogen are separated by COCH2 group has been successful even when the aryloxy ring carries weak or no electron withdrawing group. Earlier reports of such reactions involved either strong electron withdrawing groups or a special catalyst. The diphenylamines thus obtained gave analogues of diclofenac in only one case.
