6335-36-0

Usage

Uses

Used in Fragrance Industry:
1-(2,4,6-trimethyl-3-propanoyl-phenyl)propan-1-one is used as a flavoring agent in the fragrance industry for its sweet, fruity scent. It is a popular choice for enhancing the aroma in perfumes and cosmetics, contributing to their overall appeal and sensory experience.
Used in Pharmaceutical Production:
In the pharmaceutical sector, 1-(2,4,6-trimethyl-3-propanoyl-phenyl)propan-1-one serves as a key component in the manufacturing of various medications. Its unique properties make it a valuable asset in the development of new drugs and therapies.
Used as a Synthetic Intermediate in Organic Chemistry:
1-(2,4,6-trimethyl-3-propanoyl-phenyl)propan-1-one is also utilized as a synthetic intermediate in organic chemistry. Its chemical structure allows for further modification and synthesis of other complex organic compounds, expanding its applications in research and development.

Upstream product

• 79-03-8 propionyl chloride 
• 108-67-8 1,3,5-trimethyl-benzene 
• 7446-70-0 aluminium trichloride 
• 1667-01-2 2,4,6-Trimethylacetophenone 

Downstream Products

• 69187-02-6 1-[3-(2,2-Dimethyl-propionyl)-2,4,6-trimethyl-phenyl]-2,2-dimethyl-propan-1-one 

Relevant academic research and scientific papers

A Novel Friedel-Crafts Reaction of Hindered Ketones

Mesitylene has been shown to react with acetyl chloride in the presence of aluminium chloride to form 1,1-dimesitylethene.Acetomesitylene has been demonstrated to be an intermediate in the reaction, which proceeds in the second step by nucleophilic attack by the arene on the carbonyl group of acetomesitylene, which is activated by the formation of a polarized complex with aluminum chloride.Mesitylene reacts similarly with propionyl chloride, forming 1,1-dimesitylpropene; propiomesitylene is an intermediate.Steric and electronic factors responsible for this unique Friedel-Crafts reaction are discussed.

Acyclic Stereoselection. 7. Stereoselective Synthesis of 2-Alkyl-3-hydroxy Carbonyl Compounds by Aldol Condensation

The stereochemistry of the aldol condensation of preformed lithium enolates of a variety of ethyl ketones and propionic acid derivatives with aldehydes has been investigated.It is found that certain compounds give completely or nearly completely one diastereomeric enolate and that the stereostructure of the resulting aldol is correlated with the stereostructure of the enolate from which is formed.The observed stereochemistry may be understood in terms of an ordered transition state in which both oxygens are oriented in more or less the same direction.It is shown that the observed stereochemistry is kinetically controlled.In many cases, the initial aldol adduct equilibrates to furnish predominantly a threo isomer.The rate of equilibration varies widely, ranging from very fast at -60 deg C with the propiophenone-benzaldehyde adduct to slow at 25 deg C for the ethyl tert-butyl ketone-benzaldehyde adduct.The equilibration behavior of lithium ketolates is compared with that of zinc ketolates, and some differences are noted.A method for achieving erythro-threo equilibration via a chloral hemiacetal is presented.A new reagent is introduced (trimethylsilyloxy ketone 36) which may be used to stereoselectively homologate an aldehyde to an erythro α-methyl-β-hydroxy acid.As an application of the use of stereoselective aldol condensations in synthesis, (+/-)-ephedrine (48) has been synthesized from benzaldehyde in 71 percent overall yield.