6335-84-8

Usage

Uses

Used in Pharmaceutical Research:
2-(4-methoxybenzyl)benzonitrile is used as a building block for the synthesis of various pharmaceuticals. Its unique structure and reactivity contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
2-(4-methoxybenzyl)benzonitrile is also employed in the production of agrochemicals, where it serves as a key intermediate in the synthesis of active ingredients for pesticides and other agricultural chemicals.
Used in Organic Synthesis:
2-(4-methoxybenzyl)benzonitrile is used as a reagent in the synthesis of complex organic molecules. Its versatility in organic synthesis allows for the creation of a wide range of chemical products.
Used in Fine Chemicals Manufacturing:
As an important intermediate, 2-(4-methoxybenzyl)benzonitrile is utilized in the manufacturing of various fine chemicals, which are used in a multitude of applications across different industries.
Used in Biologically Active Compounds Production:
2-(4-methoxybenzyl)benzonitrile plays a crucial role in the production of biologically active compounds, which are essential in the development of new medicines and therapeutic agents. Its presence in these compounds can influence their biological activity and potential applications in healthcare.

Upstream product

• 394-47-8 2-fluorobenzonitrile 
• 161200-66-4 (4-MeOC₆H₄CH₂)Ti(O-i-Pr)3 
• 104-93-8 p-methylanizole 
• 766-46-1 2-bromo-1-ethynylbenzene 
• 623-26-7 terephthalonitrile 
• 5720-07-0 4-methoxyphenylboronic acid 
• 22115-41-9 2-(bromomethyl)benzonitrile 

Downstream Products

• 1276042-06-8 (2-(4-methoxybenzoyl)phenyl)(p-tolyl)methanone 

Relevant academic research and scientific papers

Palladium-catalyzed cross-coupling of benzyltitanium(IV) reagents with aryl fluorides

The first palladium-catalyzed cross-coupling between benzyltitanium(IV) reagents with aryl fluorides is reported. A variety of diarylmethanes can be prepared in good to excellent yields by the catalyst system of PdCl2(dppf)2 associated with 1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxypiperidine. This reaction offered a highly efficient approach to diarylmethanes that are commonly found in life-changing drug molecules. Graphical abstract: [Figure not available: see fulltext.]

Nickel catalysis enables convergent paired electrolysis for direct arylation of benzylic C-H bonds

Convergent paired electrosynthesis is an energy-efficient approach in organic synthesis; however, it is limited by the difficulty to match the innate redox properties of reaction partners. Here we use nickel catalysis to cross-couple the two intermediates

Visible-Light-Mediated Aromatic Substitution Reactions of Cyanoarenes with 4-Alkyl-1,4-dihydropyridines through Double Carbon-Carbon Bond Cleavage

Novel aromatic substitution reactions of cyanoarenes with 4-alkyl-1,4-dihydropyridines as alkylating reagents in the presence of a catalytic amount of a photoredox catalyst proceed smoothly to give the corresponding alkyl-substituted arenes in good to high yields. The present reaction system realizes a novel C-C bond-forming reaction between two fragments generated from the C-C bond-cleavage reactions of two independent substrates.

Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere via N-H imines as an intramolecular directing group

Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere was developed starting from carbonitriles and Grignard reagents via N-H imine intermediates. The present process is characterized by the following two-step sequence in a one-pot manner: (1) addition of Grignard reagents to carbonitriles to form N-H imines and (2) benzylic C-H oxygenation (C=O bond formation) triggered by 1,5-hydrogen atom transfer with transient iminyl copper species.