Welcome to LookChem.com Sign In|Join Free

CAS

  • or

6336-50-1

Post Buying Request

6336-50-1 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

6336-50-1 Usage

General Description

6-Benzyl-2-thiouracil is a chemical compound with the molecular formula C11H10N2OS. It is a derivative of uracil and is commonly used as an antithyroid agent to treat hyperthyroidism. 6-BENZYL-2-THIOURACIL works by inhibiting the production of thyroid hormones by blocking the activity of the enzyme thyroperoxidase. Additionally, 6-benzyl-2-thiouracil has also been studied for its potential anti-cancer and anti-inflammatory properties. It is a white crystalline solid that is sparingly soluble in water and is often used in laboratory research as a thyroid hormone antagonist.

Check Digit Verification of cas no

The CAS Registry Mumber 6336-50-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,3 and 6 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6336-50:
(6*6)+(5*3)+(4*3)+(3*6)+(2*5)+(1*0)=91
91 % 10 = 1
So 6336-50-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H10N2OS/c14-10-7-9(12-11(15)13-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H2,12,13,14,15)

6336-50-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-benzyl-2-sulfanylidene-1H-pyrimidin-4-one

1.2 Other means of identification

Product number -
Other names Basdene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6336-50-1 SDS

6336-50-1Relevant articles and documents

2-Arylthio-5-iodo pyrimidine derivatives as non-nucleoside HBV polymerase inhibitors

Wang, Jie,Zhang, Liang,Zhao, Jianxiong,Zhang, Yu,Liu, Qingchuan,Tian, Chao,Zhang, Zhili,Liu, Junyi,Wang, Xiaowei

, p. 1573 - 1578 (2018/02/21)

In this study, a series of 2-arylthio-5-iodo pyrimidine derivatives, as non-nucleoside hepatitis B virus inhibitors, were evaluated and firstly reported as potential anti-HBV agents. To probe the mechanism of active agents, DHBV polymerase was isolated and a non-radioisotopic assay was established for measuring HBV polymerase. The biological results demonstrated that 2-arylthio-5-iodo pyrimidine derivatives targeted HBV polymerase. In addition, pharmacophore models were constructed for future optimization of lead compounds. Further study will be performed for the development of non-nucleoside anti-HBV agents.

Synthesis and biological evaluation of novel 2-Arylalkylthio-5-iodine-6- substituted-benzyl-pyrimidine-4(3H)-ones as Potent HIV-1 Non-Nucleoside reverse transcriptase inhibitors

Zhang, Liang,Tang, Xiaowan,Cao, Yuanyuan,Wu, Shaotong,Zhang, Yu,Zhao, Jianxiong,Guo, Ying,Tian, Chao,Zhang, Zhili,Liu, Junyi,Wang, Xiaowei

, p. 7104 - 7121 (2014/07/08)

A novel series of 2-arylalkylthio-5-iodine-6-substitutedbenzyl-pyrimidine- 4(3H)- ones (S-DABOs) 8a-x had been synthesized via an efficient method. Their biological activity against HIV virus and RT assay were evaluated. Some compounds, especially 8h, 8l and 8n, displayed promising activity against HIV-1 RT with IC50 values in a range of 0.41 μM to 0.71 iM, which were much better than that of nevirapine. Molecular modeling studies revealed that the binding mode would be affected via forming an additional hydrogen bond by incorporating an oxygen atom on the C-2 side chain. The biological activity was in accordance with the docking results.

Synthesis and biological evaluation of novel C5 halogen-functionalized S-DABO as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

Qin, Hua,Liu, Chang,Guo, Ying,Wang, Ruiping,Zhang, Jianfang,Ma, Liying,Zhang, Zhili,Wang, Xiaowei,Cui, Yuxin,Liu, Junyi

scheme or table, p. 3231 - 3237 (2010/07/05)

A series of novel S-DABO analogues (4a1-5a12) have been synthesized by an efficient method and evaluated as inhibitors of human immunodeficiency virus type-1 (HIV-1). The biological testing results clearly indicated that the substitution of halogen at the C5 position of pyrimidine ring could increase the anti-HIV-1 RT activity. The most active compounds showed activity in the low micromole range with IC50 values (IC50 0.18-3.03 μM) comparable to nevirapine (IC50 4.12 μM). The docking showed that a new halogen bond was formed between halogen and carbonyl of TYR188 in the HIV-I RT.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 6336-50-1