6336-64-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
(1E)-2,3,4,5,6-pentahydroxyhexanal oxime (non-preferred name) is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable building block for the development of new drugs and pesticides.
Used as a Chelating Agent in Analytical Chemistry:
(1E)-2,3,4,5,6-pentahydroxyhexanal oxime (non-preferred name) is used as a chelating agent in analytical chemistry. Its ability to form stable complexes with metal ions makes it useful for the separation and detection of various elements.
Used as a Reagent in Organic Synthesis:
(1E)-2,3,4,5,6-pentahydroxyhexanal oxime (non-preferred name) is used as a reagent in organic synthesis. Its oxime functionality can be used to convert carbonyl groups into other functional groups, facilitating the synthesis of complex organic molecules.
Used in the Development of New Materials:
(1E)-2,3,4,5,6-pentahydroxyhexanal oxime (non-preferred name) has potential applications in the development of new materials. Its unique structure and properties may be utilized to create novel materials with specific characteristics for various industries.
Used in Drug Discovery:
(1E)-2,3,4,5,6-pentahydroxyhexanal oxime (non-preferred name) has potential applications in drug discovery. Its unique structure and properties may be explored for the development of new therapeutic agents with novel mechanisms of action.

Upstream product

• 3458-28-4 D-Mannose 
• 530-26-7 D-Mannose 
• 1990-29-0 D-altrose 

Downstream Products

• 6337-12-8 D-mannose aldonitrile peracetate 
• 71439-41-3 1,2,3,4,5-penta-O-benzoyl-D-mannonic acid nitrile 
• 105874-54-2 N-(p-Nitrobenzyliden)-β-D-mannopyranosylamin-N-oxid 
• 97834-42-9 1-Salicylidenamino-1-deoxy-D-mannit 
• 878488-20-1 C₆H₁₂N₂O₇*C₇H₉NO 

Relevant academic research and scientific papers

Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776)

Carbohydrate moieties were strategically transported from the indolocarbazole topoisomerase I (Top1) inhibitor class to the indenoisoquinoline system in search of structurally novel and potent Top1 inhibitors. The syntheses and biological evaluation of 20 new indenoisoquinolines glycosylated with linear and cyclic sugar moieties are reported. Aromatic ring substitution with 2,3-dimethoxy-8,9-methylenedioxy or 3-nitro groups exerted strong effects on antiproliferative and Top1 inhibitory activities. While the length of the carbohydrate side chain clearly correlated with antiproliferative activity, the relationship between stereochemistry and biological activity was less clearly defined. Twelve of the new indenoisoquinolines exhibit Top1 inhibitory activity equal to or better than that of camptothecin. An advanced synthetic intermediate from this study was also used to efficiently prepare indotecan (LMP400) and indimitecan (LMP776), two anticancer agents currently under investigation in a Phase I clinical trial at the National Institutes of Health.

Antioxidant activity of a water-soluble polysaccharide purified from Pteridium aquilinum

A water-soluble crude polysaccharide, obtained from fern Pteridium aquilinum, was fractionated by DEAE-Sepharose Fast-Flow column chromatography, and purified by Sephacryl S-400 HR column chromatography. The average molecular weight (Mw) of the purified polysaccharide (PLP) is 458,000 Da. The monosaccharide components of PLP were characterized by gas chromatography (GC), and the majority of the monosaccharide components was glucose (relative mass 58.1%) with low levels of galactose, mannose, rhamnose, and arabinose (relative mass 18.7%, 6.8%, 10.2%, and 6.1%, respectively). The Fourier-transform infrared spectra (FTIR) of PLP revealed typical characteristics of polysaccharides. On the basis of the ferric-reducing antioxidant power assay (FRAP), DPPH radical-scavenging, the superoxide radical assay, and self-oxidation of 1,2,3-phentriol assay, the antioxidant activities of PLP were investigated. The purified polysaccharide was demonstrated to have strong reductive power (FRAP value: 827.6 μmol/L), moderate scavenging activities against DPPH radicals (83.1%) and superoxide radicals (60.5%), and moderate inhibiting power for self-oxidation of 1,2,3-phentriol (52.4%).

126. Desoxy-nitrozucker. 13. Mitteilung. Preparation of Unprotected and Partially Protected 1-Deoxy-1-nitro-D-aldoses and Some Representative X-Ray Structure Analyses

The unprotected and partially protected 1-deoxy-1-nitro derivatives of α- and β-D-glucopyranose (see 15 and 14), β-D-mannopyranose (see 16), N-acetyl-β-D-glucosamine (see 17), β-D-galactofuranose (see 19), β-D-ribofuranose (see 20), α-D-arabinofuranose (s