6337-12-8Relevant academic research and scientific papers
Phenolics from durian exert pronounced NO inhibitory and antioxidant activities
Feng, Jianying,Wang, Yihai,Yi, Xiaomin,Yang, Weimin,He, Xiangjiu
, p. 4273 - 4279 (2016/06/15)
Durian, known as the king of fruits, is native to Southeast Asia and popular in many countries. Bioactivity-guided fractionation of the peel of durian was applied to determine its bioactive constituents. Four novel phenolics, along with 16 known, were pur
A comparative study of the neutral and acidic polysaccharides from Allium macrostemon Bunge
Zhang, Zhanjun,Wang, Fuhua,Wang, Mingchun,Ma, Liping,Ye, Hong,Zeng, Xiaoxiong
, p. 980 - 987 (2015/01/09)
Neutral and acidic polysaccharides, named AMP40N and AMP40S respectively, were isolated and purified from the dried bulbs of Allium macrostemon Bunge. Both of them showed a single and symmetrically sharp peak, indicating they were homogeneous polysaccharides. Molecular weights of AMP40N and AMP40S were determined to be 18.2 and 105.1 kDa, respectively. AMP40N was composed of arabinose and glucose, while AMP40S was composed of rhamnose, arabinose, glucose and galactose and a certain amount of uronic acid. FT-IR, periodic acid oxidation, Smith degradation, methylation and GC-MS analysis revealed that non-reducing terminal and →2,6)-Glc-(1→ existed in AMP40N and AMP40S. The glycosidic linkage of arabinose in AMP40N was →2)-Ara-(1→, whereas it was Ara-(1→ in AMP40S. AMP40S had (1→2)-linked l-rhamnose residue. Both AMP40N and AMP40S exhibited strong anti-tumor potential against human gastric carcinoma cells BGC-823, in particular, AMP40S presented significantly higher inhibitory rate of 85.94% than AMP40N of 52.63%.
Cyclopentadienyl-ruthenium(II) and iron(II) organometallic compounds with carbohydrate derivative ligands as good colorectal anticancer agents
Florindo, Pedro R.,Pereira, Diane M.,Borralho, Pedro M.,Rodrigues, Cecília M. P.,Piedade,Fernandes, Ana C.
, p. 4339 - 4347 (2015/06/08)
New ruthenium(II) and iron(II) organometallic compounds of general formula [(η5-C5H5)M(PP)Lc][PF6], bearing carbohydrate derivative ligands (Lc), were prepared and fully characterized and the crystal structures of five of those compounds were determined by X-ray diffraction studies. Cell viability of colon cancer HCT116 cell line was determined for a total of 23 organometallic compounds and SAR's data analysis within this library showed an interesting dependency of the cytotoxic activity on the carbohydrate moiety, linker, phosphane coligands, and metal center. More importantly, two compounds, 14Ru and 18Ru, matched oxaliplatin IC50 (0.45 μM), the standard metallodrug used in CC chemotherapeutics, and our leading compound 14Ru was shown to be significantly more cytotoxic than oxaliplatin to HCT116 cells, triggering higher levels of caspase-3 and -7 activity and apoptosis in a dose-dependent manner.
New dammarane-type saponins from the roots of panax notoginseng
Qiu, Li,Jiao, Yang,Huang, Gui-Kun,Xie, Ji-Zhao,Miao, Jian-Hua,Yao, Xin-Sheng
, p. 102 - 111 (2014/02/14)
Three new dammarane-type triterpenoid saponins, 1-3, were isolated and identified as (20S)-20-O-[β-D-xylopyranosyl-(1→6)-β-D- glucopyranosyl-(1→6)-β-D-glucopyranosyl]dammar-24-ene-3β, 6α,12β, 20-tetrol (1), (20S)-6-O-[(E)-but-2-enoyl-(1→6)-β- D-glucopyranosyl]dammar-24-ene-3β,6α,12β,20-tetrol (2), and (20S)-6-O-[β-D-xylopyranosyl-(1→2)-β-D-xylopyranosyl] dammar-24-ene-3β,6α,12β,20-tetrol (3) from the roots of Panax notoginseng (Burkill) F.H.Chen (Araliaceae). Their structures were elucidated on the basis of spectroscopic analyses, including 1D- and 2D-NMR techniques and HR-ESI-MS, as well as by acidic hydrolysis. Copyright
Two new compounds from the roots of Ilex pubescens
Wu, Ting,Zhang, Qing-Wen,Zhang, Xiao-Qi,Liu, Ge,Wang, Lei,Jiang, Miao-Miao,Feng, Yi-Fan,Ye, Wen-Cai
experimental part, p. 1408 - 1412 (2012/10/18)
A new triterpenoid glycoside, heterobetulinic acid 3-O - D-glucopyranosyl(1→2) - D-xylopyranoside (1), together with a new phenylacrylic acid derivative, 3S,4-dihydroxyl-2-methylene-but-1-enyl caffeate (2), were isolated from the roots of Ilex pubescens. Their structures were elucidated by HR-ESI-MS, 1-D and 2-D NMR analyses and chemical methods. In addition, the absolute configuration of 2 was established by the application of a modified Mosher's method.
A new furostanol saponin from Asparagus cochinchinensis
Shen, Yang,Xu, Cong-Li,Xuan, Wei-Dong,Li, Hui-Liang,Liu, Run-Hui,Xu, Xi-Ke,Chen, Hai-Sheng
experimental part, p. 1587 - 1591 (2012/04/10)
A new furostanol saponin, (25S)-26-O-β-d-glucopyranosyl-5β- furost-20(22)-en-3β, 15β,26-triol-3-O-[α-l-rhamnopyranosyl-(1-4) ]-β-d-glucopyranoside, namely, aspacochioside D (1) were isolated from Asparagus cochinchinensis (Lour.) Merr, along with three known saponins, aspacochioside C (2), (25S)-5β-spirostan-3β-yl-O-[O-α-L- rhamnopyranosyl-(1-4)]-β-d-glucopyranoside (3), and pseudoprotoneodioscin (4). The structure of 1 was elucidated on the basis of chemical reactions and spectral analysis (IR, GC, ESI-MS, 1H-NMR, 13C-NMR, DEPT, HMBC, HMQC and NOESY). The antiproliferative effects of 1-4 were evaluated in a cytotoxicity assay against the human tumor cell line, A549. Compound 2 (Aspacochioside C) exhibited moderate cytotoxicity against A-549, with an IC50 value of 3.87 μg/mL.
New triterpenoid sapoin from Ardisia gigantifolia Stapf.
Gong, Qiang Qiang,Mu, Li Hua,Liu, Ping,Yang, Shi Lin,Wang, Bo,Feng, Yu Lin
experimental part, p. 449 - 452 (2011/02/26)
One new triterpenoid sapoin with two known triterpenoid sapoins: 3β-O-{α-l-rhamnopyranosyl-(1 → 3)-[β-d-xylopyranose-(1 → 2)]-β-d-glucopyranosyl-(1 → 4)-α-l-arabinopyranosyl}-3β-hydroxy-13β,28-epoxy-oleanan-16-oxo-30-al (1), 3β-O-{α-l-rhamnopyranosyl-(1 →
Antioxidant activity of a water-soluble polysaccharide purified from Pteridium aquilinum
Xu, Wentao,Zhang, Fangfang,Luo, YunBo,Ma, Liyan,Kou, Xiaohong,Huang, Kunlun
experimental part, p. 217 - 222 (2009/04/11)
A water-soluble crude polysaccharide, obtained from fern Pteridium aquilinum, was fractionated by DEAE-Sepharose Fast-Flow column chromatography, and purified by Sephacryl S-400 HR column chromatography. The average molecular weight (Mw) of the purified polysaccharide (PLP) is 458,000 Da. The monosaccharide components of PLP were characterized by gas chromatography (GC), and the majority of the monosaccharide components was glucose (relative mass 58.1%) with low levels of galactose, mannose, rhamnose, and arabinose (relative mass 18.7%, 6.8%, 10.2%, and 6.1%, respectively). The Fourier-transform infrared spectra (FTIR) of PLP revealed typical characteristics of polysaccharides. On the basis of the ferric-reducing antioxidant power assay (FRAP), DPPH radical-scavenging, the superoxide radical assay, and self-oxidation of 1,2,3-phentriol assay, the antioxidant activities of PLP were investigated. The purified polysaccharide was demonstrated to have strong reductive power (FRAP value: 827.6 μmol/L), moderate scavenging activities against DPPH radicals (83.1%) and superoxide radicals (60.5%), and moderate inhibiting power for self-oxidation of 1,2,3-phentriol (52.4%).
Five furostanol saponins from fruits of Tribulus terrestris and their cytotoxic activities
Wang, Jue,Zu, Xuyu,Jiang, Yuyang
experimental part, p. 1436 - 1444 (2010/04/23)
Two new furostanol saponins, terrestroside A, 3-O-{β-D-xylopyranosyl- (1 → 3)-[ β-D-xylopyranosyl(1 → 2)] β - D-glucopyranosyl(1 → 4)-[α-L-rhamnopyranosyl(1 → 2)] β- D-galactopyranosy}-26- O -β D-glucopyranosyl-L-5a-furost-20(22)-en-(25R)-3,26-diol (1) an
