63367-12-4Relevant academic research and scientific papers
Facile one-pot preparation of 2-arylpropionic and arylacetic acids from cyanohydrins by treatment with aqueous HI
Aramini, Andrea,Sablone, Manolo R.,Bianchini, Gianluca,Amore, Alessia,Fanì, Michela,Perrone, Plinio,Dolce, Alberto,Allegretti, Marcello
experimental part, p. 2015 - 2021 (2009/07/04)
A novel one-pot two-step procedure has been developed to synthesize highly substituted 2-arylpropionic and arylacetic acids, by treatment with aqueous HI, from cyanohydrins. The hydrogenolytic reduction of α-hydroxy-2-arylpropionic acids was the key step of the process and the optimization of the reaction conditions led to identify aqueous HI as an appropriate and selective reagent for the reductive deoxygenation of cyanohydrins. The synthetic route described a general and efficient strategy for the preparation of large libraries of phenylacetic and phenylpropionic acids derivatives.
Process for the preparation of aromatic-substituted aliphatic carboxylic acids
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, (2008/06/13)
A process for the preparation of aromatic substituted carboxylic acids is disclosed. The process comprises i) forming an aromatic-substituted acrylonitrile by dehydrating a cyanohydrin of the formula STR1 where Ar is C6 to C10 aryl unsubstituted or substituted with C1 to C6 linear or branched alkyl, C1 to C6 linear or branched alkoxy, halo, amino, amino mono- or disubstituted with C1 to C6 linear or branched alkyl or carboxylic acid or the alkyl esters thereof; and R is hydrogen or C1 to C6 linear or branched alkyl; ii) catalytically reducing the aromatic-substituted acrylonitrile when not more than 10% of the cyanohydrin is converted to said acrylonitrile to form a first reaction solution comprising an aromatic substituted aliphatic nitrile; iii) hydrolyzing the aromatic-substituted aliphatic nitrile. This process is useful in the preparation of compounds that are intermediates for physiologically active aromatic substituted acetic acids similar to the profen-type compounds.
