633698-85-8

Basic information

• Product Name: 1H-Imidazole-1-carboxylic acid, 2-[4-[[[[2-[[(3-chloro-2-methylphenyl)sulfonyl]methylamino]ethoxy]acetyl] methylamino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester
• CAS NO: 633698-85-8
• Molecular Formula: C28H37ClN4O6S
• Molecular Weight: 593.144
• Mol File: 633698-85-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-1-carboxylic acid, 2-[4-[[[[2-[[(3-chloro-2-methylphenyl)sulfonyl]methylamino]ethoxy]acetyl] methylamino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-1-carboxylic acid, 2-[4-[[[[2-[[(3-chloro-2-methylphenyl)sulfonyl]methylamino]ethoxy]acetyl] methylamino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester(633698-85-8)
• EPA Substance Registry System: 1H-Imidazole-1-carboxylic acid, 2-[4-[[[[2-[[(3-chloro-2-methylphenyl)sulfonyl]methylamino]ethoxy]acetyl] methylamino]methyl]phenyl]-4,5-dihydro-, 1,1-dimethylethyl ester(633698-85-8)

Safety Data

• Hazardous Substances Data: 633698-85-8(Hazardous Substances Data)

Upstream product

• 34403-48-0 methyl-4-cyanobenzylamine 
• 633698-71-2 [2-[[(1,1-dimethylethoxy)carbonyl]methylamino]ethoxy]acetic acid 1,1-dimethylethyl ester 
• 441295-92-7 4,5-dihydro-2-[4-[(methylamino)methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 441295-90-5 [[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]methylcarbamic acid phenylmethyl ester 
• 441295-89-2 [(4-cyanophenyl)methyl]methylcarbamic acid phenylmethyl ester 
• 633698-75-6 4,5-dihydro-2-[4-[[methyl[[2-(methylamino)ethoxy]acetyl]amino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 80563-86-6 3-chloro-2-methylbenzenesulfonyl chloride 
• 633698-74-5 2-[4-(2,8-dimethyl-3,9-dioxo-11-phenyl-5,10-dioxa-2,8-diazaundec-1-yl)phenyl]-4,5-dihydro-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 633698-73-4 [2-[methyl[(phenylmethoxy)carbonyl]amino]ethoxy]acetic acid 
• 633698-72-3 [2-(methylamino)ethoxy]acetic acid trifluoroacetate 

Relevant articles and documents

From bradykinin B2 receptor antagonists to orally active and selective bradykinin B1 receptor antagonists

The bradykinin (BK) B1 receptor is an attractive target for the treatment of chronic pain and inflammation. Starting from a dual B1 and B2 antagonist, novel antagonists were designed that display low-nanomolar affinity for human B1 receptor and selectivity over B2. Initially, potent imidazoline derivatives were studied, but these compounds suffered from low bioavailability. This issue could be overcome by the use of less basic amino derivatives leading to orally active compounds.