6337-56-0

Basic information

• Product Name: 2,6-dimethylacetaminophen
• Synonyms: 2,6-dimethylacetaminophen;4-Acetylamino-3,5-dimethylphenol;4'-Hydroxy-2',6'-dimethylacetoanilide;4-Hydroxy-2,6-dimethylacetanilide;4-AcetaMido-3,5-diMethylphenol;2,6-DiMethylparacetaMol;4'-Hydroxy-2',6'-acetoxylidide;N-(4-Hydroxy-2,6-diMethylphenyl)acetaMide
• CAS NO: 6337-56-0
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 6337-56-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 349.5°C at 760 mmHg
• Flash Point: 165.2°C
• Appearance: /
• Density: 1.167g/cm³
• Vapor Pressure: 2.31E-05mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2,6-dimethylacetaminophen(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethylacetaminophen(6337-56-0)
• EPA Substance Registry System: 2,6-dimethylacetaminophen(6337-56-0)

Safety Data

• Hazardous Substances Data: 6337-56-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

4-Hydroxy-2,6-dimethylacetanilide is a useful intermediate to prepare Xylazine metabolites (1,2,3).

InChI:InChI=1/C10H13NO2/c1-6-4-9(13)5-7(2)10(6)11-8(3)12/h4-5,13H,1-3H3,(H,11,12)

Upstream product

• 74827-88-6 N-acetyl-3,5-dimethyl-1,4-benzoquinone imine 
• 81-20-9 2,6-dimethylnitrobenzene 
• 3096-63-7 N-(2,6-dimethylphenyl)hydroxylamine 
• 103901-74-2 N-(2,6-dimethylphenyl)-N-hydroxyacetamide 
• 108-68-9 3,5-Dimethylphenol 
• 166541-58-8 O-(pentafluorobenzoyl)-N-acetyl-N-(2,6-dimethylphenyl)hydroxylamine 
• 166541-50-0 O-benzoyl-N-acetyl-N-(2,6-dimethylphenyl)hydroxylamine 
• 3096-70-6 3,5-dimethyl-4-aminophenol 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 1422537-70-9 N-(2,6-dimethyl-4-oxo-1-pentyloxycyclohexa-2,5-dien-1-yl)acetamide 
• 1422537-69-6 N-(1-butoxy-2,6-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide 
• 1422537-68-5 N-(1-isopropoxy-2,6-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide 
• 1422537-67-4 N-(2,6-dimethyl-4-oxo-1-propoxycyclohexa2,5-dien-1-yl)acetamide 
• 1422537-66-3 N-(1-methoxy-2,6-dimethyl-4-oxocyclohexa-2,5-dien-1-yl)acetamide 
• 74827-89-7 4-acetamido-4-anilino-3,5-dimethyl-2,5-cyclohexadien-1-one 
• 74827-91-1 4-acetamido-3,5-dimethyl-4-(ethylthio)-2,5-cyclohexadien-1-one 
• 74827-92-2 4-acetamido-3,5-dimethyl-4-ethoxy-2,5-cyclohexadien-1-one 
• 74827-90-0 3'-chloro-2',6'-dimethyl-4'-hydroxyacetanilide 
• 527-61-7 2,6-dimethyl-1,4-benzoquinone 
• 1026163-28-9 N-[4-Hydroxy-2,6-dimethyl-3-(2-methyl-allyl)-5-piperidin-1-ylmethyl-phenyl]-acetamide 
• 186039-18-9 N-[3-Dimethylaminomethyl-4-hydroxy-2,6-dimethyl-5-(2-methyl-allyl)-phenyl]-acetamide 
• 186039-16-7 N-[4-Hydroxy-2,6-dimethyl-3-(2-methyl-allyl)-phenyl]-acetamide 
• 1027493-81-7 N-[2,6-Dimethyl-4-(2-methyl-allyloxy)-phenyl]-acetamide 

Relevant articles and documents

Redox-Neutral Selenium-Catalysed Isomerisation of para-Hydroxamic Acids into para-Aminophenols

A selenium-catalysed para-hydroxylation of N-aryl-hydroxamic acids is reported. Mechanistically, the reaction comprises an N?O bond cleavage and consecutive selenium-induced [2,3]-rearrangement to deliver para-hydroxyaniline derivatives. The mechanism is studied through both 18O-crossover experiments as well as quantum chemical calculations. This redox-neutral transformation provides an unconventional synthetic approach to para-aminophenols.

Cyclohexadienes from the rearrangement of O-aroyl-N-acetyl-N-(2,6-dimethylphenyl)hydroxylamines. Reaction in aqueous solution to meta- and para-substituted 2,6-dimethylacetanilides

O-Aryol-N-acetyl-N-(2,6-dimethylphenyl)hydroxylamines (aroyl = benzoyl, 3-nitrobenzoyl, and pentafluorobenzoyl) rearrange in acetonitrile to 1,5-dimethyl-5-aroyloxy-6-N-acetyliminocyclohexa-1,3-dienes that can be isolated as pure compounds.These cyclohexadienes react in aqueous solutions, producing m-aroyloxy- and m-hydroxy-2,6-dimethylacetanilides in an H+-catalysed reaction and the corresponding para products in a non-catalysed reaction.Analysis of the effect of the aroyloxy group suggests that the latter reaction involves heterolysis to a reactive, non-selective, ion pair that collapses to the para product, or reacts at this position with water.The meta products arise from the N-protonated cyclohexadiene reacting with solvent in a conjugate addition to give the meta-substituted phenol, or in an intramolecular reaction with the carbonyl group to give the rearranged ester.This latter reaction is proposed to proceed via an intermediate 1,3-dioxolan-2-ylium ion.The nucleophiles azide, phenylsulfinate and the methyl thioglycolate anion react in a bimolecular fashion to give meta-substituted 2,6-dimethylacetanilides.With phenylsulfinate this requires H+, while methyl thioglycolate anion reacts with the neutral cyclohexadiene.Azide exhibits reaction by both processes.These reactions are proposed to involve conjugate additions, either to the N-protonated cyclohexadiene, or, with better nucleophiles, directly on the neutral compound.These cyclohexadienes model intermediates that may form during the metabolism of certain carcinogenic amines.These results establish the presence of three electrophilic species capable of reacting with cellular nucleophiles - the highly reactive and non-selective cation formed in the heterolysis, the less reactive and more selective N-protonated species, and the neutral cyclohexadiene itself.The last electrophile is relatively unreactive, but can be a target of very good nucleophiles such as thiol anions.