63370-00-3

Upstream product

• 101-97-3 Ethyl 2-phenylethanoate 
• 75-26-3 isopropyl bromide 
• 64-17-5 ethanol 
• 124-38-9 carbon dioxide 
• 66639-74-5 2-Methyl-1-phenylallyllithium 
• 3508-94-9 3-methyl-2-phenylbutyric acid 
• 5912-93-6 1-bromo-2-methyl-1-phenyl-1-propene 
• 611-69-8 rac-2-methyl-1-phenylpropan-1-ol 
• 5558-29-2 3-methyl-2-phenyl-butyronitrile 
• 768-49-0 (2-methyl-1-propenyl)-benzene 
• 140-29-4 phenylacetonitrile 
• 582-62-7 3-methyl-1-phenylbutan-1-one 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 1061284-72-7 C₁₆H₂₃BrO₂ 

Relevant academic research and scientific papers

Stereoselective Ketone Rearrangements with Hypervalent Iodine Reagents

The first stereoselective version of an iodine(III)-mediated rearrangement of arylketones in the presence of orthoesters is described. The reaction products, α-arylated esters, are very useful intermediates in the synthesis of bioactive compounds such as ibuprofen. With chiral lactic acid-based iodine(III) reagents product selectivities of up to 73 % ee have been achieved.

Synthesis and evaluation of α,α′-disubstituted phenylacetate derivatives for T-type calcium channel blockers

We have synthesized and evaluated α,α′-disubstituted phenylacetate derivatives that were designed as T-type calcium channel blockers. Among them, compound 10e (IC50 = 8.17 ± 0.48 nM) showed the most potent T-type calcium current blocking activity and higher potency than Mibefradil (IC50 = 1.34 ± 0.49 μM). The PK profile and subtype selectivity over L-type calcium channel were satisfied for further animal assay using disease model.

2-Methyl-1-phenyl-1-propenyllithium. A Vinyllithium Derivative Showing Catalyzed Transmetalation

Full preparative and kinetic details are given for the apparent vinyl-to-allyl anion rearrangement of the title compound 1.The rapid and quantitative formation of the allyllithium derivative 7 is shown to be catalyzed by 2-methyl-1-phenyl-1-propene (2).An intermolecular transmetalation mechanism with de-aggregation and ionization steps is suggested to explain the orders of reaction, parameters of activation, and solvent dependency.