63379-16-8

Basic information

• Product Name: Carbamic acid, (4-methylphenyl)-, propyl ester
• CAS NO: 63379-16-8
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• Mol File: 63379-16-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (4-methylphenyl)-, propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (4-methylphenyl)-, propyl ester(63379-16-8)
• EPA Substance Registry System: Carbamic acid, (4-methylphenyl)-, propyl ester(63379-16-8)

Safety Data

• Hazardous Substances Data: 63379-16-8(Hazardous Substances Data)

Upstream product

• 71-23-8 propan-1-ol 
• 622-58-2 p-Tolylisocyanate 
• 627-12-3 1-propyl carbamate 
• 624-31-7 4-tolyl iodide 
• 106-38-7 para-bromotoluene 
• 590-28-3 potassium cyanate 
• 1177-35-1 2,4,6-Tris(4-methylphenoxy)-1,3,5-triazine 
• 201230-82-2 carbon monoxide 
• 540-54-5 1-Chloropropane 
• 124-38-9 carbon dioxide 
• 106-49-0 p-toluidine 
• 106-94-5 propyl bromide 
• 621-00-1 1,3-di-p-tolylurea 
• 5720-05-8 4-methylphenylboronic acid 

Downstream Products

• 73262-67-6 2-Amino-5-methyl-benzoic acid propyl ester 
• 106-49-0 p-toluidine 

Relevant articles and documents

Nickel-Catalyzed Synthesis of N-(Hetero)aryl Carbamates from Cyanate Salts and Phenols Activated with Cyanuric Chloride

A simple and efficient domino reaction has been designed and employed for the one-pot synthesis of N-(hetero)aryl carbamates through the reaction between alcohols and in-situ produced (hetero)aryl isocyanates in the presence of a nickel catalyst. The phenolic C?O bond was activated via the reaction of phenol with cyanuric chloride (2,4,6-trichloro-1,3,5-triazine (TCT)) as an inexpensive and readily available reagent. This strategy provides practical access to N-(hetero)aryl carbamates in good yields with high functional groups compatibility.

An Fe3O4@SiO2/Schiff base/Cu(ii) complex as an efficient recyclable magnetic nanocatalyst for selective mono: N-arylation of primary O-alkyl thiocarbamates and primary O-alkyl carbamates with aryl halides and arylboronic acids

An efficient, convenient and novel method for the selective mono N-arylation of primary O-alkyl thiocarbamates and primary O-alkyl carbamates with aryl halides and arylboronic acids in the presence of a recyclable magnetic Cu(ii) nanocatalyst is described. A variety of mono N-arylated O-alkyl thiocarbamates and O-alkyl carbamates were prepared in good to excellent yields with a broad range of aryl coupling partners. The magnetic nanocatalyst can be easily recovered with an external magnetic field and reused at least five times without noticeable leaching or loss of its catalytic activity. This cost-effective and eco-friendly methodology has some other advantages, such as easy preparation of the catalyst, simple workup procedure, and easy purification, which makes this protocol interesting for the users in various fields of pharmacology and biotechnology systems.

Selective Synthesis of Secondary Arylcarbamates via Efficient and Cost Effective Copper-Catalyzed Mono Arylation of Primary Carbamates with Aryl Halides and Arylboronic Acids

Abstract: An efficient, selective and cost-effective procedure has been developed for mono N-arylation of primary alkyl and benzyl carbamates with aryl iodides and bromides by incorporating CuI as an inexpensive and commercially available catalyst. Despite previous reports on C–N coupling reactions, this process does not need expensive ligands and takes advantage of readily available and inexpensive ethylenediamine (EDA) as the ligand. Reaction times were relatively short and related N-arylated carbamates were obtained in excellent yields. Interestingly, replacing CuI with Cu(OAc)2 allowed us to use arylboronic acids as coupling partner for this reaction. All products are well characterized by 1H- and 13C-NMR, MS, melting point, IR and CHNS techniques.