634-38-8

Basic information

• Product Name: 2-METHYL-QUINOLINE-4-CARBOXYLIC ACID
• Synonyms: IFLAB-BB F1371-0216;2-METHYL-QUINOLINE-4-CARBOXYLIC ACID;2-METHYL-4-QUINOLINECARBOXYLIC ACID;AKOS BBS-00003757;AKOS AU36-M132;TIMTEC-BB SBB004498;2-Methylcinchoninic acid;Aniluvitonic acid
• CAS NO: 634-38-8
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.19
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 634-38-8.mol
• Article Data: 18

Chemical Properties

• Melting Point: 245-247°C
• Boiling Point: 344.5 °C at 760 mmHg
• Flash Point: 162.2 °C
• Appearance: /
• Density: 1.285 g/cm³
• Vapor Pressure: 2.5E-05mmHg at 25°C
• Refractive Index: 1.663
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 1.15±0.10(Predicted)
• CAS DataBase Reference: 2-METHYL-QUINOLINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-QUINOLINE-4-CARBOXYLIC ACID(634-38-8)
• EPA Substance Registry System: 2-METHYL-QUINOLINE-4-CARBOXYLIC ACID(634-38-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 634-38-8(Hazardous Substances Data)

Usage

Uses

2-Methylquinoline-4-carboxylic Acid is used in preparation of dihydro pyrano pyrazol one derivatives as antitumor agents.

InChI:InChI=1/C11H9NO2/c1-7-6-9(11(13)14)8-4-2-3-5-10(8)12-7/h2-6H,1H3,(H,13,14)

Upstream product

• 1198-37-4 2,4-dimethylquinoline 
• 91-56-5 indole-2,3-dione 
• 142-04-1 aniline hydrochloride 
• 607-67-0 4-hydroxy-2-methylquinoline 
• 15226-74-1 dicobalt octacarbonyl 
• 123172-90-7 2-methylquinolin-4-yl trifluoromethanesulfonate 
• 33417-17-3 3-hydroxy-3-(2-oxopropyl)indolin-2-one 
• 67-64-1 acetone 
• 127-17-3 2-oxo-propionic acid 
• 103-70-8 Formanilid 
• 62-53-3 aniline 
• 75-07-0 acetaldehyde 
• 15821-13-3 2-methylquinoline-4-carboxamide 

Downstream Products

• 91-63-4 2-methylquinoline 
• 607-67-0 4-hydroxy-2-methylquinoline 
• 15821-13-3 2-methylquinoline-4-carboxamide 
• 7120-26-5 ethyl 2-methylquinoline-4-carboxylate 
• 90673-26-0 pyridine-2,3,4,6-tetracarboxylic acid 
• 5774-31-2 nitrofuran IIIa 
• 118967-32-1 2-styrylquinoline-4-carboxylic acid 
• 89-52-1 o-acetylamino-benzoic acid 
• 55625-40-6 methyl 2-methylquinoline-4-carboxylate 
• 6760-22-1 2-methylquinoline-4-carboxaldehyde 
• 62542-44-3 1-methyl-2-quinoline-4-carboxylic acid 
• 5416-80-8 2-methyl-1H-indole-3-carbaldehyde 

Relevant articles and documents

Study on synthesis and fluorescence property of rhodamine–naphthalene conjugate

In this study, a novel ligand (HL) consisting of 2-methyl quinoline-4-carboxylic acid, rhodamine and naphthalene moiety, was designed and synthesized, it could be developed a ratiometric fluorescent sensor for selective detection of Al3+ via fluorescence resonance energy transfer (FRET) from naphthalimide moiety to rhodamine moiety. The addition of Al3+ trigger the significant fluorescence enhancement of HL at 550 nm at the expense of the fluorescent emission of HL centered at 524 nm.

Quinoline substituted chalcone compound as well as preparation method and application thereof

The invention discloses a novel quinoline substituted chalcone compound as well as pharmaceutically acceptable salts and a preparation method thereof. The invention further discloses a pharmaceuticalcomposition which comprises a therapeutically effective amount of the novel quinoline substituted chalcone compound and/or the pharmaceutically acceptable salts and a pharmaceutically acceptable carrier. The invention further discloses a tubulin inhibitor which comprises the novel quinoline substituted chalcone compound and/or the pharmaceutically acceptable salts. The invention further disclosesapplication of the novel quinoline substituted chalcone compound and/or the pharmaceutically acceptable salts in preparing drugs for treating but not limited to colon cancer, leukemia, liver cancer, breast cancer and other diseases. The compound in the application shows excellent anti-tumor activity, and has more stable metabolic properties and better druggability prospect.

Energy efficient Pfitzinger reaction: A novel strategy using a surfactant catalyst

A novel energy efficient method for the Pfitzinger reaction is demonstrated, which is catalysed using a surfactant, cetyltrimethylammonium hydroxide. The surfactant nature of the catalyst caused the substrate to be soluble in aqueous media, which enhanced the interaction of the catalyst with the substrate. An increase in the rate of reaction and more than 78% of energy saving were observed under ultrasonic irradiation.