634-42-4

Basic information

• Product Name: N-1-naphthylbenzamide
• Synonyms: N-1-naphthylbenzamide;N-(1-Naphtyl)benzamide;N-Benzoyl-1-naphthalenamine;N-naphthalen-1-ylbenzamide
• CAS NO: 634-42-4
• Molecular Formula: C₁₇H₁₃NO
• Molecular Weight: 247.29122
• EINECS: 211-208-8
• Mol File: 634-42-4.mol
• Article Data: 68

Chemical Properties

• Boiling Point: 347.6°C at 760 mmHg
• Flash Point: 210.2°C
• Appearance: /
• Density: 1.221g/cm³
• Vapor Pressure: 5.31E-05mmHg at 25°C
• Refractive Index: 1.705
• CAS DataBase Reference: N-1-naphthylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-1-naphthylbenzamide(634-42-4)
• EPA Substance Registry System: N-1-naphthylbenzamide(634-42-4)

Safety Data

• Hazardous Substances Data: 634-42-4(Hazardous Substances Data)

Usage

General Description

N-1-naphthylbenzamide, also known as N-(1-naphthyl)benzamide, is a chemical compound with the molecular formula C18H13NO. It is a white to off-white crystalline powder with a melting point of 139-142°C. N-1-naphthylbenzamide is commonly used as a reagent in organic synthesis and in the production of pharmaceuticals. It is also used as an intermediate in the manufacture of dyes and pigments. The chemical is a potential irritant to the skin, eyes, and respiratory system, and precautions should be taken when handling and using it in laboratory and industrial settings.

InChI:InChI=1/C17H13NO/c19-17(14-8-2-1-3-9-14)18-16-12-6-10-13-7-4-5-11-15(13)16/h1-12H,(H,18,19)

Upstream product

• 110-86-1 pyridine 
• 65-85-0 benzoic acid 
• 90-11-9 1-Bromonaphthalene 
• 55-21-0 benzamide 
• 93-99-2 benzoic acid phenyl ester 
• 134-32-7 1-amino-naphthalene 
• 614-28-8 N-benzoylbenzamide 
• 98-88-4 benzoyl chloride 
• 120190-04-7 1-dibenzoylaminonaphthalene 
• 2902-69-4 2,2,2-trichloroacetophenone 
• 552-46-5 1-naphthylamine hydrochloride 
• 50-98-6 ephedrine hydrochloride 
• 74422-06-3 cis-3-benzoyl-2a,7b-dihydro-3H-cyclobutindole 
• 78945-08-1 2-nitro-benzenesulfenic acid-[1]naphthylamide 

Downstream Products

• 95490-24-7 N-(4-benzoyl-[1]naphthyl)-benzamide 
• 119656-68-7 (Benzoyl-naphthalen-1-yl-amino)-acetic acid ethyl ester 
• 3574-02-5 2-phenylnaphtho[1,2-d]oxazole 
• 1070790-61-2 N-hydroxymethyl-N-(naphthalen-1-yl)benzamide 
• 1253388-52-1 C₃₁H₂₁NO 
• 1260248-90-5 (ppy)₂Ir(N-naphthylbenzamide) 
• 24402-73-1 N-(4-nitro-1-naphthyl) benzamide 
• 873984-15-7 N-(2,4-dibenzoyl-[1]naphthyl)-benzamide 
• 859931-82-1 (3,4-diamino-[1]naphthyl)-phenyl ketone 
• 119656-53-0 N-Benzoyl-N-(1-naphthyl)glycine 
• 130576-36-2 N-chloro-N-[1]naphthyl-benzamide 

Relevant articles and documents

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Silver(I) Promoted the C4-H Bond Phosphonation of 1-Naphthylamine Derivatives with H-Phosphonates

A simple and efficient protocol for silver-promoted direct C-H phosphonation of 1-naphthylamine derivatives with H-phosphonates was described. This reaction proceeded smoothly for 1-naphthylamine derivatives at the C4 site, providing a facile and efficient route to 4-phosphonated 1-naphthylamine derivatives. This phosphonation could tolerate a diverse type of functional groups at the pyridinyl and naphthyl moieties. Further functionalization of the phosphonated product was also explored at the C2 and C8 sites, such as fluoridation, methylation, methoxylation, and amination. In addition, DFT studies of the reaction intermediate showed that the most electrophilic reactive site is at the C4 site in the naphthyl ring.

Peri -Selective Direct Acylmethylation and Amidation of Naphthalene Derivatives Using Iridium and Rhodium Catalysts

An iridium-catalyzed acylmethylation and a rhodium-catalyzed amidation of naphthalene derivatives are reported, adopting sulfoxonium ylides and dioxazolones as carbene and nitrene transfer agents, respectively. The use of SMe group as a directing group was key to ensure the peri -selective functionalization, and it can be easily removed or diversely transformed to other synthetically useful functionalities after the catalysis.