63409-02-9Relevant academic research and scientific papers
Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPARγ partial agonists
Furukawa, Akihiro,Arita, Tsuyoshi,Fukuzaki, Takehiro,Satoh, Susumu,Mori, Makoto,Honda, Takeshi,Matsui, Yumi,Wakabayashi, Kenji,Hayashi, Shinko,Araki, Kazushi,Ohsumi, Jun
, p. 1348 - 1351 (2012)
Peroxisome proliferator-activated receptor gamma (PPARγ) is a potential drug target for treating type 2 diabetes. The selective PPARγ modulators (SPPARMs), which partially activate the PPARγ transcriptional activity, are considered to improve the plasma glucose level with attenuated PPARγ related adverse effects. However, the relationships between desired pharmacological profiles and ligand specific PPARγ transcriptional profiles have been unclear. And there is also little knowledge of how to control ligand specific PPARγ transcriptional profiles. Herein, we present synthesis of novel derivatives containing substituent at naphthalene C3 position of compound 1. The novel derivatives showed various maximal efficacies as PPARγ partial agonist.
Cycloaddition of Cyclic Vinyl Ethers to an Isoquinolinium Salt: Application to the Preparation of a Model C-Naphthylglycoside
Franck, Richard W.,Gupta, Ram B.
, p. 761 - 762 (1984)
The cycloaddition of cyclic enol ethers, including sugar glycals, to 2-(2,4-dinitrophenyl)isoquinolinium chloride leads to new substituted naphthaldehydes in useful yields.
Palladium-Catalyzed Regiospecific peri- And ortho-C-H Oxygenations of Polyaromatic Rings Mediated by Tunable Directing Groups
Hu, Lihong,Jiang, Jing,Lin, Yaoyu,Ma, Congzhe,Song, Wanbin,Yuan, Dandan,Zhang, Yinan
supporting information, p. 279 - 284 (2021/01/13)
An efficient divergent approach of Pd-catalyzed C-H oxygenation of polyaromatic rings is described. Reversible directing groups enable regiospecific peri- and ortho-oxygenation to readily access a wide array of polyaromatic phenols without pre- and postmanipulation of directing groups. The systematic mechanistic investigation, including deuterium-labeling experiments, palladacycle trapping, and DFT calculations, reveals that the tunable ligand-assisted C-H bond cleavage played a crucial role during the reaction process.
Cyclization of (2-alkenylphenyl)carbonyl compounds to polycyclic arenes catalyzed by copper(II) trifluoromethanesulfonate or trifluoromethanesulfuric acid
Liu, Wei-Min,Tnay, Ya Lin,Gan, Kian Ping,Liu, Zhen-Hong,Tyan, Wan Huei,Narasaka, Koichi
, p. 1953 - 1969,17 (2012/12/12)
Various polycyclic arenes, such as naphthalenes, tetrahydroantharacenes, tetrahydrotetracenes, dihydropentacenes, and dihydropentaphenes are prepared from 2-alkenylphenyl ketones and aldehydes by the catalytic use of copper(II) trifluoromethanesulfonate (Cu(OTf)2) or trifluoromethanesulfuric acid (TfOH). Copyright
Cyclization of (2-alkenylphenyl)carbonyl compounds to polycyclic arenes catalyzed by copper(II) trifluoromethanesulfonate or trifluoromethanesulfuric acid
Liu, Wei-Min,Tnay, Ya Lin,Gan, Kian Ping,Liu, Zhen-Hong,Tyan, Wan Huei,Narasaka, Koichi
, p. 1953 - 1969 (2013/01/15)
Various polycyclic arenes, such as naphthalenes, tetrahydroantharacenes, tetrahydrotetracenes, dihydropentacenes, and dihydropentaphenes are prepared from 2-alkenylphenyl ketones and aldehydes by the catalytic use of copper(II) trifluoromethanesulfonate (Cu(OTf)2) or trifluoromethanesulfuric acid (TfOH). Copyright
Electron Transfer Activation - A Selective Photooxidation Method for the Preparation of Aromatic Adehydes and Ketones
Santamaria, Jean,Jroundi, Rachid
, p. 4291 - 4294 (2007/10/02)
A selective and mild photocatalytic procedure for benzylic oxydations with 9,10-dicyanoanthracene (DCA), an usual electron acceptor, in presence of methyl viologen (MV2+) and FeCl2 has been developped.Key words: Singlet Electron Transfer; benzylic oxidation; hydroperoxides
Cycloadditions of Isoquinolinium Salts: Vinyl Sulfide Dienophiles for the Syntheses of 1-Naphthaldehydes and Tetralins
Gupta, Ram B.,Franck, Richard W.,Onan, Kay D.,Soll, Clifford E.
, p. 1097 - 1101 (2007/10/02)
Vinyl sulfides are used as dienophiles in the Bradsher cycloaddition reaction.Processing of the cycloadducts leads to either tetralins or naphthaldehydes.The tetralins are formed with high stereoselectivity.The configuration of the products is confirmed by an X-ray structure determination.Removal of sulfur from the tetralin products affords materials that are the equivalent of having used simple alkenes as dienophiles.
ELECTRON TRANSFER ACTIVATION. HYDROPEROXIDE INTERMEDIATES IN A NOVEL AND SELECTIVE PROCEDURE FOR BENZYLIC OXIDATIONS.
Santamaria, J.,Jroundi, R.,Rigaudy, J.
, p. 4677 - 4680 (2007/10/02)
A selective and mild photochemical procedure for benzylic oxidations with 9,10-dicyanoanthracene (DCA) an usual electron acceptor, in the presence of methyl viologen (MV2+), an electron relay, has been developed.Methyl and methylene groups are oxidized in good to excellent yields to the corresponding hydroperoxides.
FORMATION OF MONOALDEHYDES BY CERIUM(IV) AMMONIUM NITRATE OXIDATION OF UNSYMMETRIC DIMETHYLNAPHTHALENES
Sydnes, Leiv K.,Hansen, Sissel H.,Burkow, Ivan C.,Saethre, Leif J.
, p. 5205 - 5208 (2007/10/02)
When 1,2-,1,3-and 1,6-dimethylnaphthalene are oxidized by Ce(4+) in acetic acid the corresponding monoaldehydes are formed in better than 80percent yield.In each case aldehyde formation takes place with a high degree of selectivity as the methyl-1-to methyl-2-naphthaldehyde ratio is better than 11:1.The selectivity may be explained from differences in reactivity as calculated within the frontier orbital method.
