6341-94-2

Upstream product

• 52-89-1 l-cysteine hydrochloride 
• 100-14-1 4-nitrobenzyl chloride 
• 52-90-4 L-Cysteine 

Downstream Products

• 101548-66-7 N-Carbobenzoxy-S-(4-nitro-benzyl)-L-cystein 
• 204693-71-0 (2R)-2-[(2S)-3-(Benzoylthio)-2-methylpropionylamino]-3-(4-nitrobenzylthio)propionic acid 
• 100816-14-6 N-Carbobenzoxy-S-(4-nitro-benzyl)-L-cysteinyl-L-alanin-methylester 
• 100029-63-8 N-Benzyloxycarbonyl-S-(4-nitro-benzyl)-L-cysteinyl-L-alanin 
• 6623-39-8 3-(4-Nitro-benzylsulfonyl)-L-alanin 
• 80839-90-3 N-Acetyl-S-(4-nitrobenzyl)-L-cysteine 
• 96079-11-7 S-(4-nitro-benzyl)-L-cysteine ethyl ester; hydrochloride 

Relevant academic research and scientific papers

Efficient S-alkylation of cysteine in the presence of 1,1,3,3- tetramethylguanidine

The synthesis of S-alkylated cysteine derivatives was carried out successfully in the presence of 1,1,3,3-tetramethylguanidine. Alkylation proceeded in high yields on unprotected amino acids and peptides containing a sulfhydryl group.

Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors

We studied synthetic modifications of N-mercaptoacylamino acid derivatives to develop a new class of leukotriene A4 (LTA4) hydrolase inhibitors. S-(4-Dimethylamino)benzyl-l-cysteine derivative 2a (SA6541) showed inhibitory activity against LTA4 hydrolase (IC50, 270 nM) and selectivity over other metallopeptidases except angiotensin-converting enzyme (ACE, IC50, 520 nM). Modification at the para-substituent of the phenyl ring of compound 2a improved LTA4 hydrolase inhibitory activity as well as selectivity over ACE. Finally, we obtained S-(4-cyclohexyl)benzy-l-cysteine derivatives 11l and 16i as potent and selective LTA4 hydrolase inhibitors.