63411-79-0

Basic information

• Product Name: 2-PYRIDIN-4-YL-1H-IMIDAZO[4,5-C]PYRIDINE
• Synonyms: 2-PYRIDIN-4-YL-1H-IMIDAZO[4,5-C]PYRIDINE;2-(4-Pyridyl)-7-azabenziMidazole, 97%;2-pyridin-4-yl-3H-imidazo[4,5-c]pyridine
• CAS NO: 63411-79-0
• Molecular Formula: C₁₁H₈N₄
• Molecular Weight: 196.20802
• Mol File: 63411-79-0.mol

Chemical Properties

• Boiling Point: 476 °C at 760 mmHg
• Flash Point: 234.6 °C
• Appearance: /
• Density: 1.336 g/cm³
• CAS DataBase Reference: 2-PYRIDIN-4-YL-1H-IMIDAZO[4,5-C]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRIDIN-4-YL-1H-IMIDAZO[4,5-C]PYRIDINE(63411-79-0)
• EPA Substance Registry System: 2-PYRIDIN-4-YL-1H-IMIDAZO[4,5-C]PYRIDINE(63411-79-0)

Safety Data

• Hazardous Substances Data: 63411-79-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyridin-4-yl-1H-imidazo[4,5-c]pyridine is used as a potential pharmacophore for drug development due to its unique structure and potential biological activities, making it a promising candidate for the creation of new therapeutic agents.
Used in Cancer Research:
2-Pyridin-4-yl-1H-imidazo[4,5-c]pyridine is used as a potential anti-cancer agent for its studied properties that may contribute to the inhibition of cancer cell growth and the modulation of oncological signaling pathways.
Used in Inflammation Management:
2-Pyridin-4-yl-1H-imidazo[4,5-c]pyridine is used as a potential anti-inflammatory agent, with its properties being investigated for their capacity to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
Used in Neurological Disorders Research:
2-Pyridin-4-yl-1H-imidazo[4,5-c]pyridine is used as a potential therapeutic agent for neurological disorders, given its potential to interact with neurological pathways and offer treatment options for various conditions affecting the nervous system.

Upstream product

• 1003-67-4 4-methylpyridine-1-oxide 
• 54-96-6 3,4-diaminopyridine 
• 55-22-1 pyridine-4-carboxylic acid 
• 3731-53-1 4-(aminomethyl)pyridine 
• 13091-23-1 4-chloro-3-nitropyridine 
• 108-89-4 picoline 
• 1681-37-4 4-amino-3-nitropyridine 

Relevant articles and documents

Weak interactions in imidazole-containing zinc(II)-based metal–organic frameworks

The self-assembly of the two zinc(II) metal–organic frameworks, [Zn2(L)(bdc)2]·3MeOH·4H2O}n (1, L = 2-(pyridin-4-yl)-3H-imidazo[4,5-c]pyridine, H2bdc = 1,4-benzenedicarboxylic acid) and [Zn2(L)(bdc)2]·2DMF·H2O}n (2), was achieved under mild reaction conditions. Both compounds 1 and 2 were structurally characterized by single-crystal X-ray diffraction analysis. Interestingly, the coordination modes of the ligand L in two structures are entirely different. Compounds 1 and 2 were made up of paddle wheel-shaped {Zn2(O2C)4} secondary building unit (SBU) clusters, which adopted three-dimensional structures with a pcu topology. Rich weak interactions were observed in the structures of both 1 and 2. The uncoordinated imidazole and pyridine moieties exhibited electron donor–acceptor interactions, π–π stacking, hydrogen bonding, and CH–π interactions. These interactions also facilitated the abilities of the framework to adsorb CO2 molecules. Gas adsorption studies revealed that compound 1 selectively adsorbed CO2 (131.1 cm3/g) over N2 (23.5 cm3/g) and H2 (36.5 cm3/g) at a pressure of 1 atm.

A one-step synthesis of substituted benzo- and pyridine-fused 1H-imidazoles

Substituted benzimidazoles and pyrimidazoles are an important group of heterocyclic aromatic organic compounds in the field of medicinal chemistry. A one-step microwave accelerated synthesis of substituted benzo- and pyridine-fused 1H-imidazoles has been described. Mechanistically, the reaction proceeds by reacting substituted 2-fluoronitrobenzene and substituted arylamine through the formation of N-hydroxy intermediate, which at higher temperature cleaves to afford the desired product. This approach achieved reductions in reaction times, higher yields, cleaner reactions than the previously described synthetic processes.

Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: From anti-pestivirus to anti-hepatitis C virus activity

A novel class of inhibitors of the hepatitis C virus [substituted 2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridines] is described. Introduction of a fluorine in position 2 of the 2-phenyl substituent of the lead anti-pestivirus compound 1 (5-[(4-bromophenyl)m

VIRAL INHIBITORS

The present invention relates to a pharmaceutical composition for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine derivative having the general formula (Z): (formula). The invention als

MODIFIED METHOD FOR THE SYNTHESIS OF 2-HETEROARYL-SUBSTITUTED IMIDAZOPYRIDINES AND BENZIMIDAZOLE

A method is proposed for the production of 2-heteroarylimidazopyridines and benzimidazole, based on the oxidation of o-nitroaminopyridine or o-nitroaniline and heteroaromatic compounds with an active methyl group by elemental sulfur.

SYNTHESIS AND PMR SPECTRA OF 2-HETARYL-SUBSTITUTED IMIDAZO-PYRIDINES AND IMIDAZOPYRIDINES

A simple method for the synthesis of 2-hetarylimidazopyridines based on the oxidation with sulfur of a mixture of p-diaminopyridine and heterocyclic compounds that contain an active methyl group is proposed.The reaction of diamines with N-oxides of α- and