63421-72-7Relevant academic research and scientific papers
Cytotoxic potential of novel 6,7-dimethoxyquinazolines
Yadav, Mange R.,Grande, Fedora,Chouhan, Bishram S.,Naik, Prashant P.,Giridhar, Rajani,Garofalo, Antonio,Neamati, Nouri
experimental part, p. 231 - 243 (2012/03/26)
Herein, we report the synthesis and cytotoxicity of a series of substituted 6,7-dimethoxyquinazoline derivatives. The cytotoxic activity of all synthesized compounds has been evaluated against HCT116p53+/+ and HCT116p53 -/- colon cancer cells and a HEY ovarian cancer cell line naturally resistant to cisplatin. Nine of the tested compounds showed significant cytotoxicity in all cell lines at 10 μM. The most promising derivative (7c) showed IC50values of 0.7 and 1.7 μM in the two colon cancer cell lines.
Synthesis and anti-inflammatory activity of 2,3-diaryl-4(3H)-quinazolinones
Yadav,Shirude,Parmar,Balaraman,Giridhar
, p. 1038 - 1045 (2008/09/16)
2,3-Diaryl-4(3H)-quinazolinones containing various substituents on diaryl rings have been synthesized and evaluated for their cyclooxygenase-2 inhibitory activity by the colorimetric COX (ovine) inhibitor screening assay and anti-inflammatory activity by the carrageenan-induced rat paw edema assay. 2-(4-Nitrophenyl)-3-(4-tolyl)-4(3H)-quinazolinone showed a maximum COX-2 inhibition of 27.72% at 22 μM concentration in the present series and exhibited a mild anti-inflammatory activity at a dose of 50 mg/kg in carrageenan-induced rat paw edema assay.
Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof
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, (2008/06/13)
Novel substituted sulfonamidobenzamides are described as useful antiarrhythmic agents. Their use in the treatment of cardiac arrhythmias, especially re-entrant arrhythmias, via the prolongation of the action potential of cardiac tissue is provided. Pharmaceutical formulations containing such compounds are also disclosed.
