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1-Benzyl 2-Methyl pyrrolidine-1,2-dicarboxylate, commonly known as bupropion, is a medication primarily used as an antidepressant and smoking cessation aid. It is a chemical compound that functions by inhibiting the reuptake of specific neurotransmitters in the brain, namely dopamine and norepinephrine. This action helps to restore the balance of these neurotransmitters, leading to improvements in mood and a reduction in nicotine cravings.
Used in Pharmaceutical Industry:
1-Benzyl 2-Methyl pyrrolidine-1,2-dicarboxylate is used as an antidepressant medication for treating major depressive disorder. It helps to alleviate symptoms of depression by restoring the balance of neurotransmitters in the brain.
1-Benzyl 2-Methyl pyrrolidine-1,2-dicarboxylate is also used as a smoking cessation aid to help people quit smoking. It reduces nicotine cravings and withdrawal symptoms, making it easier for individuals to stop smoking.
Additionally, bupropion is sometimes prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) due to its effect on neurotransmitters in the brain.
It is available in various formulations, including immediate-release and extended-release tablets, and is typically taken orally. As with any medication, bupropion can cause side effects, and it should only be used under the guidance of a healthcare professional.

63427-91-8

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63427-91-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 63427-91-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,4,2 and 7 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 63427-91:
(7*6)+(6*3)+(5*4)+(4*2)+(3*7)+(2*9)+(1*1)=128
128 % 10 = 8
So 63427-91-8 is a valid CAS Registry Number.

63427-91-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name benzyl (+/-)-2-methylproline-1-carboxylate

1.2 Other means of identification

Product number -
Other names 1-Cbz-2-methylpyrrolidine-2-carboxylic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:63427-91-8 SDS

63427-91-8Relevant academic research and scientific papers

Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor

Krainz, Tanja,Lamade, Andrew M.,Du, Lina,Maskrey, Taber S.,Calderon, Michael J.,Watkins, Simon C.,Epperly, Michael W.,Greenberger, Joel S.,Baylr, Hülya,Wipf, Peter,Clark, Robert S. B.

, p. 2868 - 2879 (2018/09/25)

The poly(ADP-ribose) polymerase (PARP) family of enzymes plays a crucial role in cellular and molecular processes including DNA damage detection and repair and transcription; indeed, PARP inhibitors are under clinical evaluation as chemotherapeutic adjunc

BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

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Page/Page column 72, (2009/08/16)

A compound having the structure set forth in Formula (I) or Formula (II): wherein the variables Y, R1, R2, R3, and R4 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

1H-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors

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Page/Page column 14, (2008/06/13)

Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of For

Preparation, Isolation and X-Ray Crystallographic Structure Determination of a Stable, Crystalline Carbonic Anhydride of an N-Protected α-Amino Acid

Chan, Chat-On,Cooksey, Christopher J.,Crich, David

, p. 777 - 780 (2007/10/02)

The reaction of methyl (2S,3aR,8aS)-2-carboxy-8-phenylsulfonyl-1,2,3,3a,8,8a-hexahydropyrrolo-indole-1-carboxylate and isobutyl chloroformate in tetrahydrofuran at -15 deg C in the presence of trimethylamine results in the formation of the correspo

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