6344-28-1

Usage

Uses

Used in Pharmaceutical Synthesis:
2-chloro-1-(4-hydroxy-3-methoxyphenyl)ethanone is used as a key intermediate in the synthesis of various pharmaceuticals due to its unique chemical properties. It serves as a building block for the development of new drugs and medicines.
Used in Skincare and Cosmetic Products:
2-chloro-1-(4-hydroxy-3-methoxyphenyl)ethanone is used as an antioxidant and anti-inflammatory agent in the development of skincare and cosmetic products. Its potential properties make it a valuable ingredient for creating effective formulations that can benefit the skin.

Upstream product

• 90-05-1 2-methoxy-phenol 
• 79-04-9 chloroacetyl chloride 
• 91-16-7 1,2-dimethoxybenzene 
• 160925-73-5 β-chloroacetoguaiacone acetate 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 54771-60-7 4-acetyl-2-methoxyphenyl acetate 
• 50893-83-9 4-acetoxy-β-bromo-3-methoxyacetophenone 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 113951-03-4 1-(4-hydroxy-3-methoxy-phenyl)-2-thiocyanato-ethanone 
• 139473-80-6 2-acetoxy-1-(4-hydroxy-3-methoxy-phenyl)-ethanone 
• 5653-20-3 3-(4-hydroxy-3-methoxy-phenyl)-3-oxo-propionitrile 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 91012-60-1 1-(4-hydroxy-3-methoxy-phenyl)-2-methylamino-ethanone 
• 1135683-19-0 C₁₅H₁₆N₂O₃S 
• 1616788-88-5 1-(4-benzyloxy-3-methoxyphenyl)-2-chloroethanone 
• 1266213-28-8 1-(4-benzyloxy-3-methoxyphenyl)-2-dimethylaminoethanone 
• 1616788-89-6 1-(4-benzyloxy-3-methoxyphenyl)-2-dimethylaminoethanol 
• 1616788-90-9 [2-(4-benzyloxy-3-methoxyphenyl)-2-phenoxyethyl]dimethylamine 
• 1616788-91-0 [2-(4-benzyloxy-3-methoxyphenyl)-2-phenoxyethyl]methylcarbamic acid ethyl ester 
• 1616788-92-1 C₂₆H₂₉NO₅ 
• 1616788-93-2 [2-(4-benzyloxy-3-methoxyphenyl)-2-(4-benzyloxyphenyl)ethyl]methylcarbamic acid ethyl ester 
• 1616788-94-3 [2-(4-benzyloxy-3-methoxyphenyl)-2-(4-benzyloxyphenyl)ethyl]methylamihe 

Relevant academic research and scientific papers

The α-chlorination of aryl methyl ketones under aerobic oxidative conditions

The novel reaction system air/ammonium nitrate/iodine/hydrochloric acid [air/NH4NO3(cat.)/I2(cat.)/HCl] is introduced as a simple, safe, cheap, efficient and regioselective mediator for the α-chlorination of aryl, heteroaryl and alkyl methyl ketones under aerobic oxidative conditions. The inventive use of a catalytic amount of iodine enabled the moderate to quantitative, regioselective chlorination of a comprehensive scope of different methyl ketone derivatives including those bearing oxidizable heteroatom (S, N) substituents, some of which possess declared potential biological and pharmaceutical activity. Air oxygen under a slight overpressure plays the role of the terminal oxidant catalytically activated by redox cycles of nitrogen oxides released from the catalytic amount of ammonium nitrate (NH4NO3) under acidic conditions of hydrochloric acid (HCl) and co-catalyzed by elemental iodine (I2), which was found to be essential for the high efficiency of the reaction system.

New synthesis of (±)-cherylline and mono- and dimethyl ethers

The synthesis of 4-aryl-1,2,3,4-tetrahydroisoquinolines is achieved via the ether rearrangement methodology. Subsequent reactions yielded cherylline and ether derivatives of amaryllidaceac alkaloids. Copyright

Preparation and properties of chlorinated syringic acids, acetosyringones, acetoguaiacones and methoxy-p-hydroquinones components of pulp bleaching effluents

A range of chlorinated phenols which serve as standards for compounds occurring in effluents from the bleaching of wood pulps with chlorine-containing reagents has been prepared. The chlorinated phenols include chlorosyringic acids, chloroacetosyringones, chloroacetoguaiacones, 5-chloro-2-methoxy-p-hydroquinone and chloro-2,6-dimethoxy-p-hydroquinones. With the exception of the ring-chlorinated acetoguaiacones which were prepared by reaction of chlorovanillin acetates with diazomethane, the compounds were obtained by direct chlorination of appropriate phenols or their acetates. Gas chromatographic and mass spectrometric data for the acetylated phenols are given.

Aryl(alkyland alkylene)-N-((phenoxy and phenylthio)alkyl) aminoheterocyclics as cardiovascular, anthihistaminic, antisecretory and antiallergy agents

A method of treating cardiac dysfunction, the effects of histamine, and gastric secretion excesses with aryl(alkyl and alkylene)-N-[(phenoxy and phenythio)alkyl]aminoheterocyclics corresponding to the formula: STR1 wherein Ar is phenyl or substituted phenyl; R is phenyl, substituted phenyl, pyridinyl or cycloalkyl; A is hydrogen, hydroxy, cyano, amido and amino; Q is --CH2 --, --CH--, or --CHOH--; d and n are zero or one and the dotted lines form double bonds consistent with the valence of carbon; p is zero, one or two; m is one to six inclusive; B is oxygen, nitrogen, sulfur, sulfinyl or sulfonyl; z is zero or one; l is zero or one; W is hydrogen, loweralkyl, halo, nitro, loweralkoxy or hydroxy; X is hydrogen, loweralkyl, halogen, loweralkoxy or hydroxy; Y is --CH(OH)CH2 OH, --CH(OH)C(O)OH, --C(O)C(O)OH, --C(O)CH2 OH,--C(O)C(O)OCH3, --C(O)C(O)OC2 H5, --CH2 C(O)OC2 H5, --CH(OH)C(O)OCH3, --CH(OH)C(O)OC2 H5 or --C(O)CH2 OC(O)CH3 ; and the pharmaceutically acceptable salts thereof; in addition to the above methods of treatment, compounds wherein (B)z is oxygen are useful in a method of treating Gell and Coombs type 1 allergic responses in mammals.