6345-85-3

Usage

InChI:InChI=1/C12H26O/c1-3-5-7-9-12(11-13)10-8-6-4-2/h12-13H,3-11H2,1-2H3

Upstream product

• 628-17-1 amyl iodide 
• 49827-36-3 methyl 2-pentylheptanoate 
• 927-49-1 dipentyl ketone 
• 4372-38-7 2,2-dipentylmalonic acid 
• 220776-75-0 diethyl 2,2-dipentylmalonate 
• 5422-52-6 α-n-pentylheptanoic acid 
• 17799-46-1 6-Methyleneundecane 

Downstream Products

• 72279-97-1 C₃₀H₄₀P⁽¹⁺⁾*C₂₄H₂₀B^(1-) 

Relevant academic research and scientific papers

COMPOUNDS USEFUL IN HIV THERAPY

The invention relates to compounds of Formula (I), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.

Cationic Lipid

The present invention provides a cationic lipid which is able to be used for nucleic acid delivery to the cytoplasm. A cationic lipid according to the present invention is, for example, a compound represented by formula (1) or a pharmaceutically acceptable salt thereof, wherein L1 and L2 independently represent an alkylene group having 3 to 10 carbon atoms; R1 and R2 independently represent an alkyl group having 4 to 24 carbon atoms or an alkenyl group having 4 to 24 carbon atoms; R3 represents an alkyl group having 1 to 3 carbon atoms; and X1 represents a single bond or CO—O—.

NOVEL AMPHIPHILIC COMPOUND HAVING DENDRONIC HYDROPHOBIC GROUP AND APPLICATION THEREOF

The present invention relates to an amphiphilic compound having a dendronic hydrophobic group, a method for preparing the same, and a method for extraction, solubilization, stabilization, or crystallization of a membrane protein by using the same. The use of the compound according to the present invention leads to an excellent membrane protein solubilization effect and a stable storage of a membrane protein in an aqueous solution for a long time, and thus can be utilized for functional analysis and structural analysis of the membrane protein. Especially, the amphiphilic compound having a dendronic hydrophobic group showed very remarkable characteristics in the visualization of protein composites through an electronic microscope. The membrane protein structural and functional analysis is one of the fields of greatest interest in current biology and chemistry, and more than half of the new drugs that are currently being developed are targeted at membrane proteins, and thus the amphiphilic compound of the present invention can be applied to membrane protein structure studies closely related to the development of new drugs.

The hydrolysis of C12 primary alkyl sulfates in concentrated aqueous solutions. Part 2. Influence of alkyl structure on hydrolytic reactivity in concentrated aqueous mixtures of sodium primary alkyl sulfates: 1-benzoyl-3-phenyl-1,2,4-triazole as a probe of water activity

The kinetics of the hydrolysis of aqueous solutions of three sodium C12-alkyl sulfates (SXS), sodium 2-methyl- undecyl sulfate (SMS), sodium cycloundecylmethyl sulfate (SCS) and sodium 2-pentylheptyl sulfate (SPS), has been investigated at concentrations up to 70% and compared with the behaviour of sodium dodecyl sulfate (SDS). The same kinetic form as previously described for SDS was observed, namely, autocatalysis by protons generated via hydrogen sulfate ion, but there were substantial variations in the reactivity as the alkyl structure changed; β-branching reduced the reactivity, particularly for SMS which was the least reactive of the surfactants studied. The patterns of reactivity by the uncatalysed and hydrogen-ion catalysed pathways for the different SXS were rather similar, but it is argued that the results are consistent with an SN2 mechanism for uncatalysed hydrolysis and the concerted SO3 cleavage (or transfer to a pre-associated water molecule)/proton transfer mechanism for the catalytic route, as previously proposed for SDS. Changes in the microenvironment of the sulfate group in aggregates formed from the different SXS are seen as being responsible for much of the rate variation. Attempts have been made to establish the dependence of observed rate constants in dilute solutions of SXS above the c.m.c. on the water activity as indicated empirically by the rate of pH-independent hydrolysis of 1-benzoyl-3-phenyl-1,2,4-triazole (BPT) in the same solutions. It appears, however, that BPT hydrolysis is not a useful guide to water activity in SXS solutions and values of d(ln k)/d(ln [H2O]) are generally much larger than expected on the basis of simple ideas of transition state composition. The effects of surfactant aggregation on the microenvironment in which chemical reactions take place are suggested to be the dominant kinetic influence both on SXS and BPT hydrolysis.