63458-19-5Relevant academic research and scientific papers
Mono/Dual Amination of Phenols with Amines in Water
Liang, Wanyi,Xie, Feng,Yang, Zhihai,Zeng, Zheng,Xia, Chuanjiang,Li, Yibiao,Zhu, Zhongzhi,Chen, Xiuwen
supporting information, p. 8291 - 8295 (2020/10/12)
We herein describe a practical direct amination of phenols through a palladium-catalyzed hydrogen-transfer-mediated activation method to synthesize the secondary and tertiary amines. In this conversion, environmentally friendly water and inexpensive ammonium formate were used as solvent and reductant, respectively. A range of amines, including aliphatic amines, aniline, secondary amines, and diamines, could be coupled effectively by this method to achieve mono/dual amination and cyclization of phenols. This study not only provides a green and mild strategy for the synthesis of secondary and tertiary naphthylamines but also expands the synthesis of chloroquine in organic chemistry.
Nickel-catalyzed amination of aryl phosphates through cleaving aryl C-O bonds
Huang, Jin-Hua,Yang, Lian-Ming
supporting information; experimental part, p. 3750 - 3753 (2011/09/14)
The amination of triaryl phosphates was achieved using a Ni(II)-(σ-Aryl) complex/NHC catalyst system in dioxane at 110 °C in the presence of NaH as base. Electron-neutral, -rich, and -deficient triaryl phosphates were coupled with a wider range of amine partners including cyclic and acyclic secondary amines, aliphatic primary amines, and anilines in good to excellent yields.
